1-((4-methoxybenzyl)oxy)-2,4-dinitrobenzene | 4287-24-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-((4-methoxybenzyl)oxy)-2,4-dinitrobenzene
• 英文别名: 1-[(4-Methoxyphenyl)methoxy]-2,4-dinitrobenzene
• CAS: 4287-24-5
• 化学式: C₁₄H₁₂N₂O₆
• 分子量: 304.259
• InChiKey: TZUBEZUXCILGDY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  110
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• THERAPEUTIC DNP DERIVATIVES AND METHODS USING SAME
  申请人：YALE UNIVERSITY

  公开号：US20160207873A1

  公开（公告）日：2016-07-21

  The present invention includes DNP derivatives of formula (I) that are useful for preventing or treating a metabolic disease or disorder in a subject in need thereof. In certain embodiments, the subject is further administered at least one additional therapeutic agent.

  本发明涉及式(I)的DNP衍生物，适用于预防或治疗需要该治疗的受试者的代谢性疾病或紊乱。在某些实施例中，该受试者进一步接受至少一种额外的治疗药物。
• PROCESS FOR PRODUCING 4-SUBSTITUTED-2-NITRO-FLUOROBENZENES
  申请人：Meiji Seika Kaisha, Ltd.

  公开号：EP1097918A1

  公开（公告）日：2001-05-09

  A process for selectively eliminating a compound of general formula (II) from a mixture of a compound of general formula (I) with the compound of general formula (II). This process comprises reacting the compound of general formula (II) with a tertiary amine and a nucleophilic agent and then washing and/or crystallizing the thus obtained compound to thereby separate the same from the mixture. A process for producing a compound represented by general formula (I) which is free from any mutagen is also provided. In these formulae, R1 represents alkyl, alkyl carbonyl or alkoxycarbonyl; and Hal represents halogeno.

  一种从通式(I)化合物与通式(II)化合物的混合物中选择性地剔除通式(II)化合物的工艺。该工艺包括使通式（II）化合物与叔胺和亲核剂反应，然后洗涤和/或结晶由此获得的化合物，从而将其从混合物中分离出来。本发明还提供了一种不含任何诱变剂的通式（I）化合物的生产工艺。在这些通式中，R1 代表烷基、烷基羰基或烷氧羰基；Hal 代表卤素。
• Therapeutic DNP derivatives and methods using same
  申请人：Yale University

  公开号：US10457629B2

  公开（公告）日：2019-10-29

  The present invention includes DNP derivatives of formula (I) that are useful for preventing or treating a metabolic disease or disorder in a subject in need thereof. In certain embodiments, the subject is further administered at least one additional therapeutic agent.

  本发明包括式（I）的 DNP 衍生物，可用于预防或治疗有需要的受试者的代谢疾病或紊乱。在某些实施方案中，受试者进一步施用至少一种额外的治疗剂。
• [EN] THERAPEUTIC DNP DERIVATIVES AND METHODS USING SAME<br/>[FR] DÉRIVÉS DE DNP THÉRAPEUTIQUES ET PROCÉDÉS LES UTILISANT
  申请人：UNIV YALE

  公开号：WO2015031598A2

  公开（公告）日：2015-03-05

  The present invention includes DNP derivatives that are useful for preventing or treating a metabolic disease or disorder in a subject in need thereof. In certain embodiments, the subject is further administered at least one additional therapeutic agent.