3-Amino-5-methyl-1-phenyl-2-pyrazolin | 50526-72-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-Amino-5-methyl-1-phenyl-2-pyrazolin
• 英文别名: 3-Amino-5-methyl-1-phenyl-pyrazolin；3-amino-5-methyl-1-phenyl-2-pyrazoline；5-methyl-1-phenyl-4,5-dihydro-1H-pyrazol-3-ylamine；3-amino-1-phenyl-5-methylpyrazoline；3-methyl-2-phenyl-3,4-dihydropyrazol-5-amine
• CAS: 50526-72-2
• 化学式: C₁₀H₁₃N₃
• 分子量: 175.233
• InChiKey: DCXDXIDSSLPEHG-UHFFFAOYSA-N

物化性质

• 熔点：
  106 °C
• 沸点：
  295.9±23.0 °C(Predicted)
• 密度：
  1.18±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-Amino-5-methyl-1-phenyl-2-pyrazolin 在 4-二甲氨基吡啶 、 乙酸酐 作用下， 以 二氯甲烷 为溶剂， 生成 1-Phenyl-5-methyl-3-acetamido-pyrazolin
  参考文献：
  名称：

  3-Trifluoroacetylamino-1-aryl-2-pyrazolines

  摘要：

  这份披露描述了新颖的3-取代氨基-1-苯基-2-吡唑烯和3-取代氨基-1-单取代和双取代苯基-2-吡唑烯及其C.sub.4和C.sub.5类似物，可用于改善关节炎疾病的炎症和/或进行性关节恶化特征，预防哮喘症状和过敏疾病的发作，或作为镇痛剂、抗菌剂或抗真菌剂。

  公开号：

  US04447442A1
• 作为产物：
  描述：

  5-methyl-1-phenyl-4,5-dihydro-1H-pyrazole 在 盐酸 、 tin(ll) chloride 作用下， 生成 3-Amino-5-methyl-1-phenyl-2-pyrazolin
  参考文献：
  名称：

  The reaction of diazonium salts with 1-aryl-Δ²-pyrazolines

  摘要：

  DOI：

  10.1039/jr9540000408

文献信息

• Therapeutically active 3-amino-1-phenyl(and substituted
  申请人：American Cyanamid Company

  公开号：US04432991A1

  公开（公告）日：1984-02-21

  This disclosure describes certain 3-amino-1-phenyl-2-pyrazolines and 3-amino-1-substituted phenyl-2-pyrazolines and their C4 and C5 analogs useful for meliorating the inflammation and/or the progressive joint deterioration characteristic of arthritic disease, preventing the onset of asthmatic symptoms and allergic diseases, or as analgesic, antibacterial or antifungal agents.

  本披露描述了某些3-氨基-1-苯基-2-吡唑烷和3-氨基-1-取代苯基-2-吡唑烷及其C4和C5类似物，可用于改善关节炎疾病的炎症和/或渐进性关节退化特征，预防哮喘症状和过敏疾病的发作，或作为镇痛、抗菌或抗真菌剂。
• 3-Trifluoroacetyl amino-1-aryl-2-pyrazolines
  申请人：American Cyanamid Company

  公开号：US04348527A1

  公开（公告）日：1982-09-07

  This disclosure describes novel 3-substituted amino-1-phenyl-2-pyrazolines and 3-substituted amino-1-mono and disubstituted phenyl-2-pyrazolines and their C.sub.4 and C.sub.5 analogs, effective as anti-inflammatory and analgesic agents, and as antibacterial agents and/or antifungal agents.

  本披露描述了新型的3-取代氨基-1-苯基-2-吡唑烷和3-取代氨基-1-单取代和双取代苯基-2-吡唑烷及其C.sub.4和C.sub.5类似物，作为抗炎和镇痛剂以及抗菌剂和/或抗真菌剂具有有效性。
• Therapeutically active 3-amino-1-phenyl and substituted
  申请人：American Cyanamid Company

  公开号：US04360680A1

  公开（公告）日：1982-11-23

  A method of treating pain, meliorating inflammation in warm-blooded animals as well as a method for treating fungal and bacterial infections in such animals using certain 3-amino-1-phenyl-2-pyrazolines and 3-amino-1-substituted phenyl-2-pyrazolines and their C4 and C5 analogs, as well as compounds used in the above are disclosed.

  本发明揭示了一种利用某些3-氨基-1-苯基-2-吡唑啉和3-氨基-1-取代苯基-2-吡唑啉及其C4和C5类似物治疗温血动物的疼痛，改善炎症，以及治疗此类动物的真菌和细菌感染的方法，以及上述所使用的化合物。
• Yellow monoazo dyes of the 2-hydroxydibenzofuran series; their preparation and use for dyeing and printing synthetic hydrophobic fibres
  申请人：Montedison S.p.A.

  公开号：EP0011295A1

  公开（公告）日：1980-05-28

  Water-insoluble yellow monoazo dyes, having the formula: wherein R, and R2 are indifferently hydrogen atoms, alkyls having up to 4 carbon atoms, phenyls, also substituted; X is an atom selected from among hydrogen, chlorine and bromine, or it is an alkyl group, an alkoxyl group, a carboxyester group having up to 4 carbon atoms, a carboxyl group, a group CF3, CN, NO2, SO2CH3, a sulphonamido group, and n is an integer selected from among 1, and 3, methods of preparation and use of the foregoing are also disclosed. The above dyes are particularly suited for the dyeing and printing of hydrophobic synthetic fibers, in particular polyester fibers, with yellow shades.

  水不溶性黄色单偶氮染料，其化学式为 其中R和R2是不同的氢原子、最多有4个碳原子的烷基、苯基，也是取代的；X是从氢、氯和溴中选取的原子，或者是烷基、烷氧基、最多有4个碳原子的羧基、羧基、CF3、CN、NO2、SO2CH3基团、磺酰胺基团，n是从1和3中选取的整数，还公开了上述染料的制备和使用方法。 上述染料特别适用于疏水性合成纤维，尤其是涤纶纤维的黄色色调的染色和印花。
• Pharmaceutical compositions containing 3-Amino-pyrazoline derivatives
  申请人：THE WELLCOME FOUNDATION LIMITED

  公开号：EP0022578A1

  公开（公告）日：1981-01-21

  Heterocyclic compounds of formula (I) and their acid addition salts exhibit anti-inflammatory activity and when administered topically do not provide the side-effects associated with their systemic administration. The novel compounds of formula (I) may be prepared by methods known in the art and may be topically administered as the compound alone or in a suitable pharmaceutical formulation.

  式 (I) 的杂环化合物 及其酸加成盐具有抗炎活性，局部用药时不会产生与全身用药相关的副作用。式（I）的新型化合物可通过本领域已知的方法制备，并可作为化合物单独或在合适的药物制剂中局部给药。