2-Amino-9-((1S,3R)-3-hydroxymethyl-2,2,3-trimethyl-cyclopentylmethyl)-9H-purin-6-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 2-Amino-9-((1S,3R)-3-hydroxymethyl-2,2,3-trimethyl-cyclopentylmethyl)-9H-purin-6-ol
• 英文别名: 2-amino-9-[[(1S,3R)-3-(hydroxymethyl)-2,2,3-trimethylcyclopentyl]methyl]-1H-purin-6-one
• 化学式: C₁₅H₂₃N₅O₂
• 分子量: 305.38
• InChiKey: WMHBKNWGRBZDNK-PSLIRLAXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  106
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (1R,cis)-3-aminomethyl-1,2,2-trimethylcyclopentylmethanol 在 盐酸 、 sodium hydroxide 、 sodium acetate 、 锌 作用下， 以 乙醇 、 水 、 溶剂黄146 、 三乙胺 、 正丁醇 为溶剂， 反应 59.0h， 生成 2-Amino-9-((1S,3R)-3-hydroxymethyl-2,2,3-trimethyl-cyclopentylmethyl)-9H-purin-6-ol
  参考文献：
  名称：

  Synthesis and Antiviral and Cytostatic Activities of Carbocyclic Nucleosides Incorporating a Modified Cyclopentane Ring. I: Guanosine Analogues

  摘要：

  Six new carbocyclic nucleosides were prepared by constructing a guanine (compounds 6, 8 and 10) or 8-azaguanine (compounds 7, 9 and 11) base on the amino group of (1R, cis)-3-(aminomethyl)-1,2,2-trimethylcyclopentylmethanol (2), and their activities against 13 viruses and 3 tumor cell lines were determined. Compounds 9, 10 and 11 showed activity against human immunodeficiency virus type 1 (HIV-1), and compound 11 also against vaccina virus, whereas compounds 6 and 7 showed some inhibition of tumor cell proliferation.

  DOI：

  10.1080/07328319708002530

文献信息

• Carbocyclic Nucleosides with a Modified Cyclopentane Skeleton
  作者：O. Caamaño、F. Fernández、G. Gómez、M. I. Nieto

  DOI：10.1080/15257779508012365

  日期：1995.5.1

  The aminoalcohol 4 has been converted into carbocyclic nucleoside analogues 2 and 3.
• Synthesis and Antiviral and Cytostatic Activities of Carbocyclic Nucleosides Incorporating a Modified Cyclopentane Ring. I: Guanosine Analogues
  作者：J. M. Blanco、O. Caamaño、F. Fernández、G. Gómez、M. I. Nieto、J. Balzarini、E. Padalko、E. De Clercq

  DOI：10.1080/07328319708002530

  日期：1997.1

  Six new carbocyclic nucleosides were prepared by constructing a guanine (compounds 6, 8 and 10) or 8-azaguanine (compounds 7, 9 and 11) base on the amino group of (1R, cis)-3-(aminomethyl)-1,2,2-trimethylcyclopentylmethanol (2), and their activities against 13 viruses and 3 tumor cell lines were determined. Compounds 9, 10 and 11 showed activity against human immunodeficiency virus type 1 (HIV-1), and compound 11 also against vaccina virus, whereas compounds 6 and 7 showed some inhibition of tumor cell proliferation.