(12bR)-7,9-dimethoxy-1,2,3,4,4a,5,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: (12bR)-7,9-dimethoxy-1,2,3,4,4a,5,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline
• 化学式: C₁₈H₂₁NO₃
• 分子量: 299.4
• InChiKey: HUNBZOBAJPISSR-QADYGRLWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  39.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Processes for the synthesis of tertiary amines
  申请人：Wang Peter X.

  公开号：US20100081819A1

  公开（公告）日：2010-04-01

  The invention provides processes for the preparation of morphinans having a tertiary amine. In particular, the present invention provides processes for the formation of tertiary amine alkaloids by direct N-alkylation of secondary amine alkaloids, the processes co-mediated by an alkylating agent and a protic solvent or a mixture of a protic solvent and an aprotic solvent.

  该发明提供了制备含有三级胺基团的吗啡醇类化合物的过程。具体来说，本发明提供了通过直接对二级胺类生物碱进行N-烷基化而形成三级胺类生物碱的过程，该过程由烷基化剂和质子溶剂或质子溶剂与非质子溶剂混合物共同介导。
• PROCESSES FOR THE ALKYLATION OF SECONDARY AMINE GROUPS OF MORPHINAN DERIVATIVES
  申请人：Mallinckrodt LLC

  公开号：EP2344506B1

  公开（公告）日：2016-02-10
• (+)-Morphinans as Antagonists of Toll-Like Receptor 9 and Therapeutic Uses Thereof
  申请人：Trawick Bobby N.

  公开号：US20110015219A1

  公开（公告）日：2011-01-20

  The present invention provides (+)-morphinans comprising Toll-like receptor 9 (TLR9) antagonist activity, as well as a method for identifying (+)-morphinans that may be therapeutically effective by determining whether the (+)-morphinan inhibits the activation of TLR9. Also provided are methods of using the (+)-morphinans comprising TLR9 antagonist activity to treat conditions such as traumatic pain, neuropathic pain, inflammatory disorders, acetaminophen toxicity, autoimmune disorders, neurodegenerative disorders, and cancer.
• US8080661B2
  申请人：——

  公开号：US8080661B2

  公开（公告）日：2011-12-20