1,2-Dimethyl-1,2-dihydropyridin | 70287-86-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1,2-Dimethyl-1,2-dihydropyridin
• 英文别名: 1,2-Dihydro-1,2-dimethylpyridine；1,2-dimethyl-2H-pyridine
• CAS: 70287-86-4
• 化学式: C₇H₁₁N
• 分子量: 109.171
• InChiKey: JTFKFVCGQRTWGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-甲基-4H-吡啶 、 正丁基锂 、 potassium tert-butylate 、 碘甲烷 生成 1,2-Dimethyl-1,2-dihydropyridin
  参考文献：
  名称：

  SCHLOSSER M.; SCHEIDER P., ANGEW. CHEM., 1979, 91, NO 6, 515-517

  摘要：

  DOI：

文献信息

• [EN] BENZYLAMINE DERIVATIVES AS INHIBITORS OF PLASMA KALLIKREIN<br/>[FR] DÉRIVÉS DE BENZYLAMINE EN TANT QU'INHIBITEURS DE KALLIKRÉINE DU PLASMA
  申请人：KALVISTA PHARMACEUTICALS LTD

  公开号：WO2013005045A1

  公开（公告）日：2013-01-10

  The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein R1 to R9 are as defined herein.

  本发明提供了如下式（I）的化合物：包含这些化合物的组合物；在治疗中使用这些化合物（例如在涉及血浆激肽酶活性的疾病或症状的治疗或预防中）；以及使用这些化合物治疗患者的方法；其中R1至R9如本文中所定义。
• Novel dyes and compositions, and processes for using same in analysis of protein aggregation and other applications
  申请人：Patton Wayne Forrest

  公开号：US20110130305A1

  公开（公告）日：2011-06-02

  Provided are dyes and compositions which are useful in a number of applications, such as the detection and monitoring protein aggregation, kinetic studies of protein aggregation, neurofibrillary plaques analysis, evaluation of protein formulation stability, protein thermal stability shift assay and analysis of molecular chaperone activity. These dyes and compositions are also useful as probes in nucleic acid and protein detection.

  提供了染料和组合物，这些染料和组合物在许多应用中非常有用，例如检测和监测蛋白质聚集、蛋白质聚集的动力学研究、神经原纤维样斑块分析、评估蛋白质配方稳定性、蛋白质热稳定性位移测定和分子伴侣活性分析。这些染料和组合物也可作为核酸和蛋白质检测中的探针。
• [EN] PROCESS FOR THE PREPARATION OF A FLUOROLACTON DERIVATIVE<br/>[FR] PROCÉDÉ DE PRÉPARATION D'UN DÉRIVÉ DE FLUOROLACTONE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2014108525A1

  公开（公告）日：2014-07-17

  A novel process for the preparation of a fluorolactone derivative of the formula (I) and of its acylated derivative of formula (V) wherein R1 stands for a hydroxy protecting group is described. The acylated fluorolactones of formula (V), particularly the benzoyl derivative with R1 =benzyl are important precursors for the synthesis of prodrug compounds which have the potential to be potent inhibitors of the Hepatitis C Virus (HCV) NS5B polymerase.

  描述了一种制备公式（I）的氟内酯衍生物和其酰化衍生物的新工艺，其中R1代表一个羟基保护基团。公式（V）的酰化氟内酯，特别是R1 =苄基的苯甲酰衍生物，是合成前药化合物的重要前体，这些前药化合物具有潜力成为对丙型肝炎病毒（HCV）NS5B聚合酶具有强效抑制作用的化合物。
• [EN] NOVEL DYES FOR THE DETECTION OR QUANTIFICATION OF DESIRABLE TARGET MOLECULES<br/>[FR] NOUVEAUX COLORANTS POUR LA DÉTECTION OU LA QUANTIFICATION DE MOLÉCULES CIBLES SOUHAITABLES
  申请人：ENZO LIFE SCIENCES INC

  公开号：WO2009014513A1

  公开（公告）日：2009-01-29

  The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins and nucleic acids. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified to provide beneficial properties.

  本发明提供了染料、反应性染料和标记试剂，可用于检测或定量所需的目标分子，如蛋白质和核酸。所提供的染料可在溶液中自由使用，染料与目标分子的结合提供信号生成。还提供了包含反应性基团的染料，可用于将染料连接到将结合到所需目标分子的探针上。本发明的新型染料经过改性以提供有益性能。
• Use of Quaternary Pyridinium Compounds for Vasoprotection and/or Hepatoprotection
  申请人：MARCINEK Andrzej

  公开号：US20080221172A1

  公开（公告）日：2008-09-11

  The invention relates to a method for the treatment or prevention of diseases or conditions associated with vascular endothelium dysfunction or liver injury comprising the administration to a patient in a need of such treatment or prevention of a therapeutically or prophylactically effective amount of a compound selected from the group consisting of: wherein R represents hydrogen atom, CH 3 , OH, pyridyl (C 5 H 4 N), 1-methylpyridyl (C 5 H 4 N—CH 3 ) or pyridyl substituted with hydroxy group ((OH)C 5 H 3 N), and X represents a physiologically acceptable counterion.

  该发明涉及一种治疗或预防与血管内皮功能障碍或肝损伤相关的疾病或病况的方法，包括向需要此类治疗或预防的患者施用所述治疗或预防有效量的化合物，所述化合物选自以下组合：其中R代表氢原子、CH3、OH、吡啶基（C5H4N）、1-甲基吡啶基（ - ）或带有羟基取代的吡啶基（（OH）C5H3N），X代表生理上可接受的对离子。