triphenyl 3-phenylpropylphosphorane

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: triphenyl 3-phenylpropylphosphorane
• 英文别名: triphenyl(3-phenylpropyl)-λ5-phosphane
• 化学式: C₂₇H₂₇P
• 分子量: 382.485
• InChiKey: YCQLRIXXWUOUSS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1-benzyl-3-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]-4-piperidone 、 triphenyl 3-phenylpropylphosphorane 在 sodium 作用下， 以 二甲基亚砜 为溶剂， 生成 1-Benzyl-3-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]-4-(3-phenylpropylidene)piperidine
  参考文献：
  名称：

  3-[2-Hydroxy-4-(substituted)-phenyl]azacycloalkanes and derivatives

  摘要：

  氮杂环烷及其衍生物，包括不饱和类似物，每个在3位具有一个2-羟基-4-取代苯基团，其中4位取代基是可以在链中具有氧原子的烷基，或者可以在烷基链中具有氧原子的芳基烷基，它们用于药理学和药用目的，以及它们的中间体和制备过程。

  公开号：

  US04147872A1

文献信息

• TRICYCLIC INDOLE DERIVATIVES USEFUL ENDOTHELIAL LIPASE INHIBITORS
  申请人：Janssen Pharmaceutica, NV

  公开号：US20130210806A1

  公开（公告）日：2013-08-15

  The present invention is directed to tricyclic indole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by endothelial lipase, for example, cardiovascular disorders.

  本发明涉及三环吲哚衍生物、包含它们的制药组合物，以及它们在治疗受内皮细胞脂肪酶调节的疾病和病况，例如心血管疾病中的应用。
• 3-[2-Hydroxy-4-(substituted)phenyl]azacycloalkanols and derivatives
  申请人：Pfizer Inc.

  公开号：US04387229A1

  公开（公告）日：1983-06-07

  Azacycloalkanes, and derivatives thereof, including unsaturated analogs, each of which has at the 3-position a 2-hydroxy-4-substituted phenyl group wherein the 4-position substituent is alkyl which can have an oxygen atom as part of the chain, or aralkyl which can have an oxygen atom as part of the alkyl chain, their use for pharmacological and medicinal purposes, intermediates therefor and processes for their preparation.

  Azacycloalkanes及其衍生物，包括不饱和类似物，每个在3位置具有2-羟基-4-取代苯基基团的化合物，其中4位置取代基是可以作为链的一部分具有氧原子的烷基或可以作为烷基链的一部分具有氧原子的芳基烷基，它们用于药理和医学目的，其中间体和制备它们的过程。
• 3-[2,4-(Disubstituted)-phenyl]azacycloalkanones as analgesics
  申请人：Pfizer Inc.

  公开号：US04263438A1

  公开（公告）日：1981-04-21

  Azacycloalkanes, and derivatives thereof, including unsaturated analogs, each of which has at the 3-position a 2-hydroxy-4-substituted phenyl group wherein the 4-position substituent is alkyl which can have an oxygen atom as part of the chain, or aralkyl which can have an oxygen atom as part of the alkyl chain, their use for pharmacological and medicinal purposes, intermediates therefor and processes for their preparation.

  Azacycloalkanes及其衍生物，包括不饱和类似物，每个分子在3位具有一个2-羟基-4-取代苯基基团，其中4位取代基是烷基，可以将氧原子作为链的一部分，或是芳基烷基，可以将氧原子作为烷基链的一部分。这些化合物可用于药理学和医学目的，其中间体以及制备它们的方法。
• 3-(2-Hydroxy-4-(substituted)phenyl)azacycloalkanes as analgesics
  申请人：Pfizer, Inc.

  公开号：US04332942A1

  公开（公告）日：1982-06-01

  Azacycloalkanes, and derivatives thereof, including unsaturated analogs, each of which has at the 3-position a 2-hydroxy-4-substituted phenyl group wherein the 4-position substituent is alkyl which can have an oxygen atom as part of the chain, or aralkyl which can have an oxygen atom as part of the alkyl chain, their use for pharmacological and medicinal purposes, intermediates therefor and processes for their preparation.

  Azacycloalkanes及其衍生物，包括不饱和类似物，每个分子在3位具有2-羟基-4-取代苯基团，其中4位取代基是烷基，可以在链中具有氧原子，或是芳基烷基，可以在烷基链中具有氧原子，它们用于药理和医学目的，中间体及其制备方法。
• Iap binding compounds
  申请人：Shi Yigong

  公开号：US20070032437A1

  公开（公告）日：2007-02-08

  Compounds that bind cellular IAPs (inhibitor of apoptosis proteins) are disclosed. The compounds are mimetics of the N-terminal tetrapeptide of IAP-binding proteins, such as Smac/DIABOLO, IIid. Grim and Reaper, which interact with a specific surface groove of IAP. Also disclosed are methods of using these compounds for therapeutic, diagnostic and assay purposes.

  本文披露了能够结合细胞IAP（凋亡抑制蛋白）的化合物。这些化合物是IAP结合蛋白（如Smac / DIABOLO，IIid Grim和Reaper）N末端四肽的类似物，它们与IAP的特定表面凹槽相互作用。此外，本文还披露了使用这些化合物进行治疗，诊断和检测的方法。