2-[4-Amino(ethyl)-2-methylanilino]-1-ethanol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[4-Amino(ethyl)-2-methylanilino]-1-ethanol
• 英文别名: 2-(4-amino-N-ethyl-2-methylanilino)ethanol
• 化学式: C₁₁H₁₈N₂O
• 分子量: 194.27
• InChiKey: FXWLIOZHGLWASU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  49.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-[4-Amino(ethyl)-2-methylanilino]-1-ethanol 、 硫酸 在 氮气 、 氧气 、 乙醇 、 水 作用下， 反应 3.17h， 以The acid salt product, N-ethyl-N-(2-hydroxyethyl)-2-methyl-p-phenylenediamine sulfate, was formed as a white precipitate的产率得到N-ethyl-N-(2-hydroxyethyl)-2-methyl-p-phenylenediamine sulfate
  参考文献：
  名称：

  METHOD FOR PURIFYING FREE-BASE P-PHENYLENEDIAMINE-TYPE PHOTOGRAPHIC COLOR DEVELOPERS

  摘要：

  一种用于纯化游离态p-苯二胺显色剂的方法。该方法包括将含有p-苯二胺游离基显色剂的溶液经过短程蒸馏，其中至少包括下列一种：降膜蒸发器、薄膜蒸发器、刮板蒸发器或短程蒸馏器。另一方面，该方法还包括制备p-苯二胺游离基显色剂酸盐的方法。该方法包括以下步骤：a）将经过短程蒸馏过程得到的纯化的p-苯二胺游离基溶解在有机溶剂中；b）将溶解的游离基馏分物与适当的矿酸接触；c）以酸盐形式结晶显色剂。

  公开号：

  US20030017426A1

文献信息

• Method for preparing an acid salt of p-phenylenediamine-type photographic color developers
  申请人：——

  公开号：US20030022114A1

  公开（公告）日：2003-01-30

  A process for purifying p-phenylenediamine color developers in their free-base form. The process includes subjecting a solution containing p-phenylenediamine-type free base color developer to short path distillation which includes at least one of falling film evaporator, thin film evaporator, wiped film evaporator, or short-path evaporator. Another aspect is a method for preparing an acid salt from a p-phenylenediamine free base color developer. The method includes the steps of: a) dissolving a purified p-phenylenediamine free base derived from the short path distillation process in an organic solvent; b) contacting the dissolved free base distillate with an appropriate mineral acid; and c) crystallizing the color developer in the acid salt form.

  一种用于纯化游离基形式的p-苯二胺显影剂的过程。该过程包括将含有p-苯二胺型游离基显影剂的溶液经过短程蒸馏，其中包括至少一个下降薄膜蒸发器、薄膜蒸发器、刮板蒸发器或短程蒸馏器。另一个方面是从p-苯二胺游离基显影剂制备酸盐的方法。该方法包括以下步骤：a）将从短程蒸馏过程中获得的纯化p-苯二胺游离基溶解在有机溶剂中；b）将溶解的游离基馏分与适当的矿酸接触；c）以酸盐形式结晶显影剂。
• Silver halide photographic material
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0313021A1

  公开（公告）日：1989-04-26

  A silver halide photographic material having provided on a support, at least one red sensitive emulsion layer comprising a silver halide emulsion having a silver chloride content of from 90 to 100 mol% and spectrally sensitized by a red sensitizing dye having a reduction potential at a value of -1.27 (V vs SCE) or more negative and a nitrogen-containing heterocyclic compound, exhibits reduced fluctuation in photographic sensitivity depending on the change in the printing temperature and reduced fluctuation in photographic sensitivity due to long term storage under the normal condition.

  一种卤化银感光材料，在支架上至少有一层红色感光乳剂层，该层由氯化银含量为 90 至 100 摩尔%的卤化银乳剂组成，并由还原电位为-1.27（V vs SCE）或更负值的红色感光染料和含氮杂环化合物进行光谱感光。
• Catalytic signal enhancement for lateral flow immunoassays
  申请人：The Government of the United States of America, as represented by the Secretary of the Navy

  公开号：US11209429B2

  公开（公告）日：2021-12-28

  The present invention provides a method for increasing the sensitivity of LFIAs by using palladium nanoparticles, selecting appropriate dye chemistries, and improving the timing of the development chemistry. In the presence of a palladium nanoparticle, three reagents interact with a catalytic label to form a colored dye. The three reagents include a hydrogen peroxide source, a color developer (a substituted para-phenylenediamine), and a color coupler (e.g. a napthol or a phenol). The timing of the development chemistry is improved by any combination of using a reducing agent, delaying hydrogen peroxide application by diffusion, using dissolving materials as a time delay, using serpentine flow, and separating the color coupler and the color developer on the strip.

  本发明提供了一种通过使用钯纳米粒子、选择适当的染料化学成分和改进显影化学时间来提高 LFIAs 灵敏度的方法。在钯纳米粒子存在的情况下，三种试剂与催化标签相互作用，形成彩色染料。这三种试剂包括过氧化氢源、显色剂（取代对苯二胺）和颜色耦合剂（如萘酚或苯酚）。使用还原剂、通过扩散延迟过氧化氢的使用、使用溶解材料作为时间延迟、使用蛇形流以及在条带上分离颜色耦合剂和显色剂等任何组合都可以改善显色化学反应的时间。
• CATALYTIC PARTICLES FOR SIGNAL ENHANCEMENT FOR LATERAL FLOW IMMUNOASSAYS
  申请人：The Government of the United States of America, as represented by the Secretary of the Navy

  公开号：US20190339265A1

  公开（公告）日：2019-11-07

  The present invention provides a method for preparing catalytic particles and using them for increased sensitivity in lateral flow immunoassays. Palladium salt is reduced in the presence of a protein using sodium borohydride as a reducing agent to form brown or gray particles. These particles catalytically develop a dye to detect the presence of an analyte.
• US3990896A
  申请人：——

  公开号：US3990896A

  公开（公告）日：1976-11-09