5-[2-[(4-氯苯基)甲基氨基]吡啶-4-基]-4-(3-甲基苯基)-1,3-噻唑-2-胺 | 303163-31-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 5-[2-[(4-氯苯基)甲基氨基]吡啶-4-基]-4-(3-甲基苯基)-1,3-噻唑-2-胺
• 英文名称: N-[4-[2-amino-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]-N-(chlorobenzyl)amine
• 英文别名: N-[4-[2-amino-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]-N-(4-chlorobenzyl)amine；5-[2-[(4-chlorophenyl)methylamino]pyridin-4-yl]-4-(3-methylphenyl)-1,3-thiazol-2-amine
• CAS: 303163-31-7
• 化学式: C₂₂H₁₉ClN₄S
• 分子量: 406.939
• InChiKey: FYRBCHDLDPYQFN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  92.1
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  [5-(2-fluoro-pyridin-4-yl)-4-(3-methylphenyl)-1,3-thiazol-2-yl]amine 、 对氯苄胺 生成 5-[2-[(4-氯苯基)甲基氨基]吡啶-4-基]-4-(3-甲基苯基)-1,3-噻唑-2-胺
  参考文献：
  名称：

  5-PYRIDYL-1,3-AZOLE COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF

  摘要：

  公开号：

  EP1180518B1

文献信息

• MEDICINAL COMPOSITIONS
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1402900A1

  公开（公告）日：2004-03-31

  The present invention relates to an agent for the prophylaxis or treatment of pain, an agent for suppressing activation of osteoclast, and an inhibitor of osteoclast formation, which contains a p38 MAP kinase inhibitor and/or a TNF-α production inhibitor.

  本发明涉及一种用于预防或治疗疼痛的药剂，一种用于抑制破骨细胞活化的药剂，以及一种包含p38 MAP激酶抑制剂和/或TNF-α产生抑制剂的破骨细胞形成抑制剂。
• CONCOMITANT DRUGS
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1354603A1

  公开（公告）日：2003-10-22

  The present invention relates to a pharmaceutical agent containing one or more kinds of a p38 MAP kinase inhibitor and/or a TNF-α production inhibitor and one or more kinds of drugs selected from the group consisting of (1) a non-steroidal antiinflammatory drug, (2) a disease-modifying anti-rheumatic drug, (3) an anti-cytokine drug, (4) an immunomodulator, (5) a steroid and (6) a c-Jun N-terminal kinase inhibitor in combination. This combination agent is useful as a prophylactic or therapeutic agent of the diseases such as rheumatism, arthritis and the like, and other diseases.

  本发明涉及一种含有一种或多种p38 MAP激酶抑制剂和/或TNF-α产生抑制剂以及从（1）非甾体抗炎药、（2）疾病修饰性抗风湿药、（3）抗细胞因子药物、（4）免疫调节剂、（5）类固醇和（6）c-Jun N末端激酶抑制剂中选择的一种或多种药物的药物制剂。这种组合药剂可用作预防或治疗风湿病、关节炎等疾病以及其他疾病的药物。
• Medicinal compositions
  申请人：Ohkawa Shigenori

  公开号：US20050080113A1

  公开（公告）日：2005-04-14

  The present invention relates to an agent for the prophylaxis or treatment of pain, an agent for suppressing activation of osteoclast, and an inhibitor of osteoclast formation, which contains a p38 MAP kinase inhibitor and/or a TNF-α production inhibitor.

  本发明涉及一种用于预防或治疗疼痛的药剂，一种用于抑制成骨细胞活化的药剂，以及一种抑制成骨细胞形成的抑制剂，其中包含p38 MAP激酶抑制剂和/或TNF-α生产抑制剂。
• 5-pyridyl-1,3-azole compounds, process for producing the same and use thereof
  申请人：Ohkawa Shigenori

  公开号：US20060135566A1

  公开（公告）日：2006-06-22

  An optionally N-oxidized compound represented by the formula: wherein R 1 represents hydrogen, hydrocarbon, heterocycle, amino, acyl, R 2 represents an aromatic group, R 3 represents hydrogen, pyridyl, aromatic hydrocarbon, X represents oxygen, optionally oxidized sulfur, Y represents a bond, an oxygen, optionally oxidized sulfur, a group represented by the formula NR 4 (R 4 represents hydrogen, hydrocarbon or acyl) and Z represents a bond or a divalent acyclic hydrocarbon, or a salt thereof has an excellent adenosine A 3 receptor antagonistic activity and is used as an agent for preventing or treating diseases related to an adenosine A 3 receptor. Furthermore, the compound (I) or a salt thereof has p38 MAP kinase inhibitory activity and TNF-α inhibitory activity and is used as an agent for preventing or treating diseases related to p38 MAP kinase and diseases related to TNF-α.

  一种可选氧化的化合物，其化学式表示为：其中R1代表氢、烃基、杂环、氨基、酰基，R2代表芳香基团，R3代表氢、吡啶基、芳香烃基，X代表氧、可选氧化硫，Y代表键、氧、可选氧化硫、由公式NR4（R4代表氢、烃基或酰基）表示的基团，Z代表键或二价非环烷基，或其盐具有出色的腺苷A3受体拮抗活性，并用作预防或治疗与腺苷A3受体相关的疾病的药物。此外，化合物(I)或其盐具有p38 MAP激酶抑制活性和TNF-α抑制活性，并用作预防或治疗与p38 MAP激酶相关的疾病和与TNF-α相关的疾病的药物。
• 5-pyridyl-1, 3-azole compounds, process for producing the same and use there of
  申请人：Ohkawa Shigenori

  公开号：US20090048307A1

  公开（公告）日：2009-02-19

  An optionally N-oxidized compound represented by the formula: wherein R 1 represents hydrogen, hydrocarbon, heterocycle, amino, acyl, R 2 represents an aromatic group, R 3 represents hydrogen, pyridyl, aromatic hydrocarbon, X represents oxygen, optionally oxidized sulfur, Y represents a bond, an oxygen, optionally oxidized sulfur, a group represented by the formula NR 4 (R 4 represents hydrogen, hydrocarbon or acyl) and Z represents a bond or a divalent acyclic hydrocarbon, or a salt thereof has an excellent adenosine A 3 receptor antagonistic activity and is used as an agent for preventing or treating diseases related to an adenosine A 3 receptor. Furthermore, the compound (I) or a salt thereof has p38 MAP kinase inhibitory activity and TNF-α inhibitory activity and is used as an agent for preventing or treating diseases related to p38 MAP kinase and diseases related to TNF-α.

  一种可选择氧化的化合物，其化学式表示为：其中R1表示氢，碳氢化合物，杂环，氨基，酰基，R2表示芳香基团，R3表示氢，吡啶基，芳香烃，X表示氧，可选择氧化的硫，Y表示键，氧，可选择氧化的硫，一个由公式NR4（R4表示氢，碳氢化合物或酰基）表示的基团和Z表示键或二价无环碳氢化合物，或其盐具有出色的腺苷A3受体拮抗活性，并用作预防或治疗与腺苷A3受体相关的疾病的药剂。此外，该化合物（I）或其盐具有p38 MAP激酶抑制活性和TNF-α抑制活性，并用作预防或治疗与p38 MAP激酶和TNF-α相关的疾病的药剂。