2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ium-1-yl)-3-(1,2,4-triazol-1-yl)propan-2-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ium-1-yl)-3-(1,2,4-triazol-1-yl)propan-2-ol
• 化学式: C₁₃H₁₂F₂N₆O*H
• 分子量: 307.283
• InChiKey: RFHAOTPXVQNOHP-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  83.5
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-ium-1-yl)-3-(1,2,4-triazol-1-yl)propan-2-ol 、 β-环糊精 在 盐酸 作用下， 以 水 、 二甲基亚砜 为溶剂， 生成
  参考文献：
  名称：

  氟康唑的质子化和β-环糊精复合物形成平衡

  摘要：

  氟康唑是念珠菌感染的适当抗真菌剂，用于量化其酸碱和环糊精复合物形成平衡。1H NMR-pH 滴定揭示了在强碱性区域 (log K1 = 11.96) 和酸性区域 (log K2 = 1.48) 中的质子化步骤。通过一维和二维溶液核磁共振光谱技术研究了其与β-环糊精（2-羟基）丙基-β-环糊精和磺丁基醚-β-环糊精的配合物的稳定性和结构。氟康唑的环糊精复合物具有中等稳定性（1 < log K < 2）。奇怪的是，在中性氟康唑和β-环糊精之间形成了两种稳定性相当的异构体复合物。

  DOI：

  10.1007/s10847-016-0595-2

文献信息

• DEVICES AND METHODS FOR WOUND TREATMENT
  申请人：Applied Tissue Technologies LLC

  公开号：EP3558185A1

  公开（公告）日：2019-10-30
• DEVICES AND METHODS FOR NEGATIVE PRESSURE THERAPY
  申请人：Applied Tissue Technologies LLC

  公开号：EP4087629A1

  公开（公告）日：2022-11-16
• [EN] DEVICES AND METHODS FOR WOUND TREATMENT<br/>[FR] DISPOSITIFS ET PROCÉDÉS POUR LE TRAITEMENT DES PLAIES
  申请人：APPLIED TISSUE TECH LLC

  公开号：WO2018119442A1

  公开（公告）日：2018-06-28

  Devices and methods for wound treatment are disclosed. A chamber may define a treatment space having an interior engineered surface including a plurality of structures configured to provide pathways for the distribution of negative pressure and to exert mechanical stress on a wound. One or more tubes may be in fluid communication with the treatment space to facilitate the application of negative pressure, the introduction of therapeutic agents, and the removal of wound material. Therapeutic agents may be formulated with a gel, for example, a hydrogel, a hydrocolloid, alginate, methyl cellulose, gelatin or any other gels for sustained-release and enhanced usability. A wound fluid collection device including an absorbable material may interface with the wound treatment device to facilitate the collection and disposal of wound material.
• [EN] DEVICES AND METHODS FOR NEGATIVE PRESSURE THERAPY<br/>[FR] DISPOSITIFS ET MÉTHODES DE THÉRAPIE PAR PRESSION NÉGATIVE
  申请人：APPLIED TISSUE TECH LLC

  公开号：WO2021142293A1

  公开（公告）日：2021-07-15

  Devices and methods for edema management, e.g., reducing edema, are disclosed. A treatment device may include a chamber defining a treatment space, the chamber being fabricated from a substantially impermeable material and configured to conform to the shape of the periphery, an inner surface of the chamber including a plurality of surface patterns, the chamber having a sealing portion at a base; and at least one conduit connected to the chamber and in fluid communication with the treatment space so as to enable the application of a negative pressure to the treatment space. The treatment device may be configured for reducing edema at a target site on a subject. The treatment device may be further configured for edema management, e.g., reducing edema, of at least one breast, e.g., both breasts, of a subject.