3'-Deoxy-thymidin-5'-diphosphat | 37960-17-1

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷酸
• 英文名称: 3'-Deoxy-thymidin-5'-diphosphat
• 英文别名: Deoxy-thymidine diphosphate；[(2S,5R)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl phosphono hydrogen phosphate
• CAS: 37960-17-1
• 化学式: C₁₀H₁₆N₂O₁₀P₂
• 分子量: 386.192
• InChiKey: BZDVTEPMYMHZCR-JGVFFNPUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.9
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  172
• 氢给体数：
  4
• 氢受体数：
  10

文献信息

• INORGANIC-ORGANIC HYBRID COMPOUNDS INCLUDING ORGANIC PLATINUM-CONTAINING ANIONS, FOR USE IN MEDICINE
  申请人：Karlsruher Institut fur Technologie

  公开号：US20210292353A1

  公开（公告）日：2021-09-23

  The present invention relates to inorganic-organic hybrid compounds for use in medicine or for use as medication, consisting of an inorganic metal cation and an organic platinum-containing cytostatic anion, in particular also a cisplatin derivative.

  本发明涉及用于医学或作为药物使用的无机-有机杂化化合物，包括无机金属阳离子和含有铂的细胞静止阴离子，特别是顺铂衍生物。
• [EN] NUCLEOSIDE AND NUCLEOTIDE DERIVATIVES<br/>[FR] DÉRIVÉS DE NUCLÉOSIDES ET DE NUCLÉOTIDES
  申请人：ENANTA PHARM INC

  公开号：WO2016033164A1

  公开（公告）日：2016-03-03

  The present invention discloses compounds of formula (I), or a pharmaceutically acceptable salt thereof: (I) which inhibit, preventing or treating abnormal cellular proliferation and/or a viral infection, particularly by HIV, HCV or HBV. Consequently, the compounds of the present invention interfere with the replication cycle of a virus and are also useful as antiviral agents, or interfere with host cellular biochemical process and are also useful as antiproliferative agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from viral infection and/or cell proliferation. The invention also relates to methods of treating a viral infection and/or cell proliferation in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention relates to novel antiviral/anti-proliferative compounds represented herein above, pharmaceutical compositions comprising such compounds, and methods for the treatment or prophylaxis of viral infection in a subject in need of such therapy with said compounds.

  本发明揭示了化合物(I)或其药学上可接受的盐，该化合物可抑制、预防或治疗异常细胞增殖和/或病毒感染，特别是HIV、HCV或HBV感染。因此，本发明的化合物干扰病毒的复制周期，也可用作抗病毒剂，或干扰宿主细胞的生化过程，也可用作抗增殖剂。本发明还涉及包含上述化合物的制药组合物，用于治疗患有病毒感染和/或细胞增殖的受试者。本发明还涉及通过给予包含本发明化合物的制药组合物来治疗受试者的病毒感染和/或细胞增殖的方法。本发明涉及上述新型抗病毒/抗增殖化合物，包括这些化合物的制药组合物，以及使用这些化合物治疗或预防受需要的受试者的病毒感染的方法。
• Verfahren zum Identifizieren von fungizid wirksamen Verbindungen basierend auf Thymidylat-Kinasen
  申请人：Bayer CropScience AG

  公开号：EP1612276A1

  公开（公告）日：2006-01-04

  Die Erfindung bezieht sich auf ein Verfahren zum Identifizieren von Fungiziden, die Verwendung von Thymidylat-Kinase zum Identifizieren von Fungiziden, die Verwendung von Inhibitoren der Thymidylat-Kinase als Fungizide und Verfahren zum Bekämpfen pflanzenpathogener Pilze.

  本发明涉及一种鉴定杀真菌剂的方法、使用胸苷酸激酶鉴定杀真菌剂、使用胸苷酸激酶抑制剂作为杀真菌剂以及防治植物病原真菌的方法。
• Sheet or tubular structure consisting of elastic biocompatible material and its use
  申请人：Charité - Universitätsmedizin Berlin

  公开号：EP2067494A1

  公开（公告）日：2009-06-10

  The present invention relates to a sheet or tubular structure consisting of biocompatible material, which is elastic and comprises at least one biologically active substance in at least one region and to a sheet or tubular structure, which comprises at least one biologically active substance release-modifying agent in at least one region as well as an implant covered at least partially by the sheet or tubular structure of the invention. The present invention further provides a method and an apparatus for producing, and preferably customizing and/or optimizing, the sheet or tubular structure of the invention. The sheet or tubular structure of the invention can be customized/optimized before implantation in the operating room.

  本发明涉及一种由生物相容性材料构成的片状或管状结构，该结构具有弹性，并在至少一个区域中包含至少一种生物活性物质；本发明还涉及一种片状或管状结构，该结构在至少一个区域中包含至少一种生物活性物质释放调节剂，以及至少部分由本发明的片状或管状结构覆盖的植入物。本发明进一步提供了一种生产本发明片状或管状结构的方法和设备，最好是定制和/或优化本发明片状或管状结构的方法和设备。本发明的片状或管状结构可在手术室植入前进行定制/优化。
• Methods using pores
  申请人：ISIS INNOVATION LIMITED

  公开号：EP2272981A1

  公开（公告）日：2011-01-12

  The invention relates to a method of identifying an individual nucleotide, comprising (a) contacting the nucleotide with a transmembrane protein pore so that the nucleotide interacts with the pore and (b) measuring the current passing through the pore during the interaction and thereby determining the identity of the nucleotide. The invention also relates to a method of sequencing nucleic acid sequences and kits related thereto.

  本发明涉及一种识别单个核苷酸的方法，包括：(a)将核苷酸与跨膜蛋白孔接触，使核苷酸与孔相互作用；(b)测量相互作用期间通过孔的电流，从而确定核苷酸的身份。本发明还涉及一种核酸序列测序方法及相关试剂盒。