(2-Benzo[1,3]dioxol-5-yl-2,3-dihydro-benzo[b]thiophen-3-yl)-methanol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: (2-Benzo[1,3]dioxol-5-yl-2,3-dihydro-benzo[b]thiophen-3-yl)-methanol
• 英文别名: [2-(1,3-Benzodioxol-5-yl)-2,3-dihydrobenzothiophen-3-yl]methanol；[2-(1,3-benzodioxol-5-yl)-2,3-dihydro-1-benzothiophen-3-yl]methanol
• 化学式: C₁₆H₁₄O₃S
• 分子量: 286.351
• InChiKey: PGGROEUIFFBULR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  64
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-benzo[1,3]dioxol-5-yl-2,3-dihydro-benzo[b]thiophene-3-carboxylic acid methyl ester 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 以81%的产率得到(2-Benzo[1,3]dioxol-5-yl-2,3-dihydro-benzo[b]thiophen-3-yl)-methanol
  参考文献：
  名称：

  Synthesis and antifungal activity of some 2-aryl-3-hydroxymethylbenzo[b]thiophenes

  摘要：

  This paper describes the preparation of a series of 2-aryl-3-hydroxymethylbenzo[b]thiophenes and 2-aryl-3-hydroxymethyl-2,3-dihydrobenzo[b]thiophenes. All of the products were examined for antifungal activity and many of the compounds displayed good activity against Cryptococcus neoformans, Torulopsis glabrata and Trichosporon cutaneum.

  DOI：

  10.1016/0223-5234(92)90031-u

文献信息

• Synthesis and antifungal activity of some 2-aryl-3-hydroxymethylbenzo[b]thiophenes
  作者：TAI Nakib、MJ Meegan、AM Looney、ML Burke

  DOI：10.1016/0223-5234(92)90031-u

  日期：1992.12

  This paper describes the preparation of a series of 2-aryl-3-hydroxymethylbenzo[b]thiophenes and 2-aryl-3-hydroxymethyl-2,3-dihydrobenzo[b]thiophenes. All of the products were examined for antifungal activity and many of the compounds displayed good activity against Cryptococcus neoformans, Torulopsis glabrata and Trichosporon cutaneum.