[2-(4-Dimethylamino-phenyl)-2,3-dihydro-benzo[b]thiophen-3-yl]-methanol

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: [2-(4-Dimethylamino-phenyl)-2,3-dihydro-benzo[b]thiophen-3-yl]-methanol
• 英文别名: [2-(4-Dimethylaminophenyl)-2,3-dihydrobenzothiophen-3-yl]methanol；[2-[4-(dimethylamino)phenyl]-2,3-dihydro-1-benzothiophen-3-yl]methanol
• 化学式: C₁₇H₁₉NOS
• 分子量: 285.41
• InChiKey: RMFOZAUWVBJGDW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  48.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-(4-dimethylamino-phenyl)-2,3-dihydro-benzo[b]thiophene-3-carboxylic acid methyl ester 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 以49%的产率得到[2-(4-Dimethylamino-phenyl)-2,3-dihydro-benzo[b]thiophen-3-yl]-methanol
  参考文献：
  名称：

  Synthesis and antifungal activity of some 2-aryl-3-hydroxymethylbenzo[b]thiophenes

  摘要：

  This paper describes the preparation of a series of 2-aryl-3-hydroxymethylbenzo[b]thiophenes and 2-aryl-3-hydroxymethyl-2,3-dihydrobenzo[b]thiophenes. All of the products were examined for antifungal activity and many of the compounds displayed good activity against Cryptococcus neoformans, Torulopsis glabrata and Trichosporon cutaneum.

  DOI：

  10.1016/0223-5234(92)90031-u

文献信息

• Synthesis and antifungal activity of some 2-aryl-3-hydroxymethylbenzo[b]thiophenes
  作者：TAI Nakib、MJ Meegan、AM Looney、ML Burke

  DOI：10.1016/0223-5234(92)90031-u

  日期：1992.12

  This paper describes the preparation of a series of 2-aryl-3-hydroxymethylbenzo[b]thiophenes and 2-aryl-3-hydroxymethyl-2,3-dihydrobenzo[b]thiophenes. All of the products were examined for antifungal activity and many of the compounds displayed good activity against Cryptococcus neoformans, Torulopsis glabrata and Trichosporon cutaneum.