5-Phenethylpyrimidine-2,4,6-triamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-Phenethylpyrimidine-2,4,6-triamine
• 英文别名: 5-(2-phenylethyl)pyrimidine-2,4,6-triamine
• 化学式: C₁₂H₁₅N₅
• 分子量: 229.28
• InChiKey: HAUXUMNDBGEUDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• [EN] GAL3 ANTAGONISTS FOR THE TREATMENT OF NEUROPATHIC PAIN<br/>[FR] ANTAGONISTES DE GAL3 DESTINES AU TRAITEMENT DE DOULEURS NEUROPATHIQUES
  申请人：SYNAPTIC PHARMA CORP

  公开号：WO2004014307A2

  公开（公告）日：2004-02-19

  This invention is directed to pyrimidine and indolone derivatives which are selective antagonists for the GAL3 receptor and are useful for the treatment of neuropathic pain and other abnormalities. This invention also provides a method of treating a subject suffering from an abnormality which comprises administering to the subject an amount of a compound of the invention effective to treat the subject's abnormality. This invention also provides a method of treating an abnormality in a subject which comprises administering to the subject a composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a GAL3 receptor antagonist.