3-(2-chlorophenothiazin-10-yl)-N,N-dimethyl-propan-1-amine; (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-(2-chlorophenothiazin-10-yl)-N,N-dimethyl-propan-1-amine; (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• 英文别名: potassium;3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine;(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
• 化学式: C33H36ClKN4O4S2
• 分子量: 691.3
• InChiKey: HTQQVOYPSGNVPA-HBRCYENSSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  1.42
• 重原子数：
  45
• 可旋转键数：
  8
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  147
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Use of oxygen antagonists for the therapeutic treatment of mammals
  申请人：Fred Hutchinson Cancer Research Center

  公开号：EP2363022A2

  公开（公告）日：2011-09-07

  There is provided the use of oxygen antagonists for inducing stasis in cells, tissues and/or organs in vivo or in an organism overall. It includes methods and apparatuses for achieving stasis in any of these biological materials, so as to preserve and/or protect them. In specific embodiments, therapeutic methods and apparatuses for organ transplantation, hyperthermia, wound healing, hemorrhagic shock, cardioplegia for bypass surgery, neurodegeneration, hypothermia and cancer is provided.

  本发明提供了使用氧拮抗剂诱导体内或整个生物体内的细胞、组织和/或器官停滞的方法。它包括在任何这些生物材料中实现停滞的方法和装置，以便保存和/或保护它们。在具体的实施方案中，提供了用于器官移植、热疗、伤口愈合、失血性休克、旁路手术的心脏麻痹、神经变性、低体温和癌症的治疗方法和装置。
• USE OF OXYGEN ANTAGONISTS FOR EX VIVO PRESERVATION OF TISSUES OR ORGANS
  申请人：Fred Hutchinson Cancer Research Center

  公开号：EP2949212A1

  公开（公告）日：2015-12-02

  There is provided the use of oxygen antagonists for inducing stasis in cells, tissues and/or organs in vivo or in an organism overall. It includes methods and apparatuses for achieving stasis in any of these biological materials, so as to preserve and/or protect them. In specific embodiments, therapeutic methods and apparatuses for organ transplantation, hyperthermia, wound healing, hemorrhagic shock, cardioplegia for bypass surgery, neurodegeneration, hypothermia and cancer is provided.

  本发明提供了使用氧拮抗剂诱导体内或整个生物体内的细胞、组织和/或器官停滞的方法。它包括在任何这些生物材料中实现停滞的方法和装置，以便保存和/或保护它们。在具体的实施方案中，提供了用于器官移植、热疗、伤口愈合、失血性休克、旁路手术的心脏麻痹、神经变性、低体温和癌症的治疗方法和装置。
• PHOTOTOXICITY OR PHOTOALLERGY MEASUREMENT METHOD AND REAGENT FOR USE IN SAID MEASUREMENT METHOD
  申请人：FUJIFILM Corporation

  公开号：EP3901620A1

  公开（公告）日：2021-10-27

  Provided are a method for measuring the phototoxicity or photoallergy of a test substance without using animals and a reagent for use therein. The method for measuring phototoxicity or photoallergy includes reacting a test substance with an organic compound that is an N-(arylalkylcarbonyl)cysteine or an α-N-(arylalkylcarbonyl)lysine under irradiation with ultraviolet light; reacting the test substance with the organic compound without irradiation with ultraviolet light; determining the depletion of the organic compound after each reaction by an optical measurement; and detecting phototoxicity or photoallergy from the difference between the depletion of the organic compound after the reaction under irradiation with ultraviolet light and the depletion of the organic compound after the reaction without irradiation with ultraviolet light.

  本发明提供了一种不使用动物而测量受试物质光毒性或光过敏性的方法以及用于该方法的试剂。这种测量光毒性或光过敏性的方法包括：在紫外线照射下，使受试物质与 N-(芳基烷基羰基)半胱氨酸或 α-N-(芳基烷基羰基)赖氨酸的有机化合物反应；在没有紫外线照射的情况下，使受试物质与有机化合物反应；通过光学测量确定每次反应后有机化合物的损耗量；根据在紫外线照射下反应后有机化合物的损耗量与在未用紫外线照射的情况下反应后有机化合物的损耗量之间的差值检测光毒性或光过敏性。
• Methods, compositions and devices for inducing stasis in cells, tissues, organs, and organisms
  申请人：Roth B. Mark

  公开号：US20050136125A1

  公开（公告）日：2005-06-23

  The present invention concerns the use of oxygen antagonists for inducing stasis in cells, tissues, and/or organs in vivo or in an organism overall. It includes methods and apparatuses for achieving stasis in any of these biological materials, so as to preserve and/or protect them. In specific embodiments, therapeutic methods and apparatuses for organ transplantation, hyperthermia, wound healing, hemorrhagic shock, cardioplegia for bypass surgery, neurodegeneration, hypothermia, and cancer is provided.

  本发明涉及使用氧拮抗剂诱导体内或整个生物体内的细胞、组织和/或器官停滞。它包括在任何这些生物材料中实现停滞的方法和装置，以便保存和/或保护它们。在具体的实施方案中，提供了用于器官移植、热疗、伤口愈合、失血性休克、旁路手术的心脏麻痹、神经变性、低体温和癌症的治疗方法和装置。
• Methods, compositions and devices for inducing stasis in tissues and organs
  申请人：Roth B. Mark

  公开号：US20050147692A1

  公开（公告）日：2005-07-07

  The present invention concerns the use of oxygen antagonists for inducing stasis in tissue, including all or part of organs. It includes methods and apparatuses for achieving stasis in tissue, so as to preserve and/or protect them. In specific embodiments, preservation methods and apparatuses for preserving tissue for transplantation purposes is provided.

  本发明涉及使用氧拮抗剂诱导组织停滞，包括全部或部分器官。本发明包括实现组织停滞的方法和装置，以便保存和/或保护组织。在具体的实施方案中，本发明提供了为移植目的保存组织的保存方法和装置。