2-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-3H-benzimidazole-5-carboxamidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-3H-benzimidazole-5-carboxamidine
• 英文别名: 2-[2-(4-methoxyphenyl)-3H-benzimidazol-5-yl]-3H-benzimidazole-5-carboximidamide
• 化学式: C₂₂H₁₈N₆O
• 分子量: 382.4
• InChiKey: ZUMPAEXRWOLVKS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  117
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• Amidine derivatives for treating amyloidosis
  申请人：Chalifour J. Robert

  公开号：US20070021483A1

  公开（公告）日：2007-01-25

  The present invention relates to the use of amidine compounds in the treatment of amyloid-related diseases. In particular, the invention relates to a method of treating or preventing an amyloid-related disease in a subject comprising administering to the subject a therapeutic amount of an amidine compound. Among the compounds for use according to the invention are those according to the following Formula, such that, when administered, amyloid fibril formation, neurodegeneration, or cellular toxicity is reduced or inhibited:

  本发明涉及在治疗与淀粉样相关疾病中使用氨基脲类化合物。特别地，本发明涉及一种治疗或预防受试者淀粉样相关疾病的方法，包括向受试者施用治疗剂量的氨基脲类化合物。根据本发明使用的化合物包括以下化学式的化合物，当施用时，可减少或抑制淀粉样纤维形成、神经退行性或细胞毒性：
• Dicationic compounds which selectively recognize G-quadruplex DNA
  申请人：Wilson W. David

  公开号：US20100249175A1

  公开（公告）日：2010-09-30

  Dicationic compounds that are highly selective for binding G-quadruplex DNA are described. Several compounds exhibit groove binding toward G-quadruplex DNA and in vitro and in vivo activity versus Trypanosoma brucei rhodesiense. The compounds represent novel drugs for the treatment of cancer, malaria, leishmania, and trypanosomiasis.

  本文描述了高度选择性结合G四链体DNA的二阳离子化合物。几种化合物对G四链体DNA表现出凹槽结合的特性，并在体内外显示出对Trypanosoma brucei rhodesiense的活性。这些化合物代表了治疗癌症、疟疾、利什曼病和锥虫病的新型药物。