3-(Benzylsulfanylmethyl)-6-bromo-8-methyl-imidazo[1,2-a]pyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 3-(Benzylsulfanylmethyl)-6-bromo-8-methyl-imidazo[1,2-a]pyridine
• 英文别名: 3-(benzylsulfanylmethyl)-6-bromo-8-methylimidazo[1,2-a]pyridine
• 化学式: C₁₆H₁₅BrN₂S
• 分子量: 347.279
• InChiKey: OLFKNMHREQHHSQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  42.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  6-溴-8-甲基-咪唑并[1,2-a]吡啶 在 sodium acetate 、 溶剂黄146 作用下， 反应 2.0h， 生成 3-(Benzylsulfanylmethyl)-6-bromo-8-methyl-imidazo[1,2-a]pyridine
  参考文献：
  名称：

  Synthesis of Imidazo[1,2-a]pyridines as Antiviral Agents

  摘要：

  The synthesis of original imidazo[1,2-a]pyridines bearing a thioether side chain at the 3 position and their antiviral activity are reported. From the synthesized compounds, 4, 15, and 21 were highly active against human cytomegalovirus with a therapeutic index superior to 150. These compounds also showed pronounced activity against varicella-zoster virus. Their structure-activity relationship is discussed.

  DOI：

  10.1021/jm981051y

文献信息

• Synthesis of Imidazo[1,2-<i>a</i>]pyridines as Antiviral Agents
  作者：Alain Gueiffier、Sylvie Mavel、Mohammed Lhassani、Ahmed Elhakmaoui、Robert Snoeck、Graciela Andrei、Olivier Chavignon、Jean-Claude Teulade、Myriam Witvrouw、Jan Balzarini、Erik De Clercq、Jean-Pierre Chapat

  DOI：10.1021/jm981051y

  日期：1998.12.1

  The synthesis of original imidazo[1,2-a]pyridines bearing a thioether side chain at the 3 position and their antiviral activity are reported. From the synthesized compounds, 4, 15, and 21 were highly active against human cytomegalovirus with a therapeutic index superior to 150. These compounds also showed pronounced activity against varicella-zoster virus. Their structure-activity relationship is discussed.