methyl N-[1-[2-[4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-2-oxo-1H-pyridin-3-yl]-7-methyl-3H-benzimidazol-5-yl]piperidin-4-yl]carbamate | 752196-87-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: methyl N-[1-[2-[4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-2-oxo-1H-pyridin-3-yl]-7-methyl-3H-benzimidazol-5-yl]piperidin-4-yl]carbamate
• CAS: 752196-87-5
• 化学式: C₂₈H₃₁ClN₆O₄
• 分子量: 551.045
• InChiKey: VZGOJYYBQQYRJE-HSZRJFAPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  39
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  132
• 氢给体数：
  5
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  3-[6-(4-aminopiperidin-1-yl)-4-methyl-1H-benzimidazol-2-yl]-4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-1H-pyridin-2-one 、 氯甲酸甲酯 在 N,N-二异丙基乙胺 作用下， 以 甲醇 为溶剂， 生成 methyl N-[1-[2-[4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-2-oxo-1H-pyridin-3-yl]-7-methyl-3H-benzimidazol-5-yl]piperidin-4-yl]carbamate
  参考文献：
  名称：

  Balancing oral exposure with Cyp3A4 inhibition in benzimidazole-based IGF-IR inhibitors

  摘要：

  3-(Benzimidazol-2-yl)-pyridine-2-one-based ATP competitive inhibitors of Insulin-like Growth Factor 1 Kinase (IGF-IR) were optimized for reduced Cyp3A4 inhibition and improved oral exposure. The use of malonate as methyl anion synthon via SNAr reaction and double decarboxylation under mild conditions is demonstrated. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.05.104

文献信息

• US7223757B2
  申请人：——

  公开号：US7223757B2

  公开（公告）日：2007-05-29
• Balancing oral exposure with Cyp3A4 inhibition in benzimidazole-based IGF-IR inhibitors
  作者：Kurt Zimmermann、Mark D. Wittman、Mark G. Saulnier、Upender Velaparthi、David R. Langley、Xiaopeng Sang、David Frennesson、Joan Carboni、Aixin Li、Ann Greer、Marco Gottardis、Ricardo M. Attar、Zheng Yang、Praveen Balimane、Lorell N. Discenza、Dolatrai Vyas

  DOI：10.1016/j.bmcl.2008.05.104

  日期：2008.7

  3-(Benzimidazol-2-yl)-pyridine-2-one-based ATP competitive inhibitors of Insulin-like Growth Factor 1 Kinase (IGF-IR) were optimized for reduced Cyp3A4 inhibition and improved oral exposure. The use of malonate as methyl anion synthon via SNAr reaction and double decarboxylation under mild conditions is demonstrated. (c) 2008 Elsevier Ltd. All rights reserved.