[[(2S,4R,5R)-5-(4-amino-5-methyl-2-oxo-pyrimidin-1-yl)-4-hydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: [[(2S,4R,5R)-5-(4-amino-5-methyl-2-oxo-pyrimidin-1-yl)-4-hydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate
• 英文别名: [[(2S,4R,5R)-5-(4-amino-5-methyl-2-oxopyrimidin-1-yl)-4-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
• 化学式: C₁₀H₁₈N₃O₁₃P₃
• 分子量: 481.18
• InChiKey: RXTCTPLOUMZDKR-LKEWCRSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.1
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  248
• 氢给体数：
  6
• 氢受体数：
  13

文献信息

• Method for the treatment or prevention of flavivirus infections using nucleoside analogues
  申请人：——

  公开号：US20020019363A1

  公开（公告）日：2002-02-14

  The present invention relates to a method for the treatment or prevention of Flavivirus infections using nucleoside analogues in a host comprising administering a therapeutically effective amount of a compound having the formula I or a pharmaceutically acceptable salt thereof.

  本发明涉及一种使用核苷类似物在宿主体内治疗或预防黄病毒感染的方法，包括给予具有公式I或其药学上可接受的盐的治疗有效量的化合物。
• Method for the treatment or prevention of Flavivirus infections using nucleoside analogues
  申请人：——

  公开号：US20040248844A1

  公开（公告）日：2004-12-09

  The present invention relates to a method for the treatment or prevention of Flavivirus infections using nucleoside analogues in a host comprising administering a therapeutically effective amount of a compound having the formula I or a pharmaceutically acceptable salt thereof.