Ac-PAVVFVTRKN-NH2

• 分子结构分类: 有机化合物 - 有机聚合物 - 多肽
• 英文名称: Ac-PAVVFVTRKN-NH2
• 英文别名: (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-acetylpyrrolidine-2-carbonyl]amino]propanoyl]amino]-3-methyl-butanoyl]amino]-3-methyl-butanoyl]amino]-3-phenyl-propanoyl]amino]-3-methyl-butanoyl]amino]-3-hydroxy-butanoyl]amino]-5-guanidino-pentanoyl]amino]-6-amino-hexanoyl]amino]butanediamide；(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-acetylpyrrolidine-2-carbonyl]amino]propanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxybutanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-6-aminohexanoyl]amino]butanediamide
• 化学式: C₅₄H₉₀N₁₆O₁₃
• 分子量: 1171.41
• InChiKey: XSWKRSABEBUFIY-BGAKPTBYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.2
• 重原子数：
  83
• 可旋转键数：
  35
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  479
• 氢给体数：
  15
• 氢受体数：
  15

反应信息

• 作为产物：
  描述：

  Fmoc-L-缬氨酸 、 Fmoc-L-丙氨酸 、 Fmoc-L-脯氨酸 、 Fmoc-L-苯丙氨酸 、 乙酸酐 、 alkaline earth salt of/the/ methylsulfuric acid 生成 Ac-PAVVFVTRKN-NH2
  参考文献：
  名称：

  Anti-HIV-1 peptides derived from partial amino acid sequences of CC-Chemokine RANTES

  摘要：

  Fifteen acetyl-peptide-amides with partial amino acid sequences of RANTES (regulated upon activation, normal T-cell expressed and secreted), all Cys residues of which were substituted by Ala, were synthesized, and screened for anti-HIV-1 activity. Peptides corresponding to 1-10. 37-46. and 57-68 showed marked activity against CC-chemokine receptor 5-using HIV-1(JR-CSF) (% inhibition at 100 nM 69, 82 76%, respectively). The results indicate that multiple regions, including the N-terminal part responsible for chemotactic activity. are involved in anti-HIV-1 activity of RANTES, yielding possible lead compounds for anti-HIV-1 agents. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(02)00271-7

文献信息

• Anti-HIV-1 peptides derived from partial amino acid sequences of CC-Chemokine RANTES
  作者：Yasuhiro Nishiyama、Tsutomu Murakami、Suguru Shikama、Keisuke Kurita、Naoki Yamamoto

  DOI：10.1016/s0968-0896(02)00271-7

  日期：2002.12

  Fifteen acetyl-peptide-amides with partial amino acid sequences of RANTES (regulated upon activation, normal T-cell expressed and secreted), all Cys residues of which were substituted by Ala, were synthesized, and screened for anti-HIV-1 activity. Peptides corresponding to 1-10. 37-46. and 57-68 showed marked activity against CC-chemokine receptor 5-using HIV-1(JR-CSF) (% inhibition at 100 nM 69, 82 76%, respectively). The results indicate that multiple regions, including the N-terminal part responsible for chemotactic activity. are involved in anti-HIV-1 activity of RANTES, yielding possible lead compounds for anti-HIV-1 agents. (C) 2002 Elsevier Science Ltd. All rights reserved.