(-)-(4S,5S)-2-(2-chlorophenyl)-4,5-diphenyl-1,3-bis((R)-1-phenylethyl)imidazolidine | 891271-43-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (-)-(4S,5S)-2-(2-chlorophenyl)-4,5-diphenyl-1,3-bis((R)-1-phenylethyl)imidazolidine
• 英文别名: (4S,5S)-2-(2-chlorophenyl)-4,5-diphenyl-1,3-bis[(1R)-1-phenylethyl]imidazolidine
• CAS: 891271-43-5
• 化学式: C₃₇H₃₅ClN₂
• 分子量: 543.151
• InChiKey: JNXZKNIAKFTTBE-SFSFMBGESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.2
• 重原子数：
  40
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (-)-(4S,5S)-2-(2-chlorophenyl)-4,5-diphenyl-1,3-bis((R)-1-phenylethyl)imidazolidine 在 N-溴代乙酰胺 、 六氟磷酸钾 作用下， 以 乙二醇二甲醚 、 氯仿 、 水 为溶剂， 反应 1.5h， 以94%的产率得到(-)-(4S,5S)-2-(2-chlorophenyl)-4,5-diphenyl-1,3-bis((R)-1-phenylethyl)imidazolinium hexafluorophosphate
  参考文献：
  名称：

  The preparation of new enantiopure imidazolinium salts and their evaluation as catalysts and shift reagents

  摘要：

  A series of new chiral imidazolinium salts were prepared and tested as catalysts. It was possible to show that bis-imidazolinium salts had a higher reactivity than mono-imidazolium salts. In addition a chiral discrimination of the bis-imidazolinium salts with the potassium salt of racemic Mosher's acid wits proven by NMR studies. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2006.02.021
• 作为产物：
  描述：

  2-氯苯甲醛 、 (1S,2S)-1,2-diphenyl-N,N'-bis((R)-1-phenylethyl)ethane-1,2-diamine 在 对甲苯磺酸 作用下， 以 苯 为溶剂， 反应 48.0h， 以50%的产率得到(-)-(4S,5S)-2-(2-chlorophenyl)-4,5-diphenyl-1,3-bis((R)-1-phenylethyl)imidazolidine
  参考文献：
  名称：

  The preparation of new enantiopure imidazolinium salts and their evaluation as catalysts and shift reagents

  摘要：

  A series of new chiral imidazolinium salts were prepared and tested as catalysts. It was possible to show that bis-imidazolinium salts had a higher reactivity than mono-imidazolium salts. In addition a chiral discrimination of the bis-imidazolinium salts with the potassium salt of racemic Mosher's acid wits proven by NMR studies. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2006.02.021

文献信息

• The preparation of new enantiopure imidazolinium salts and their evaluation as catalysts and shift reagents
  作者：Václav Jurčík、René Wilhelm

  DOI：10.1016/j.tetasy.2006.02.021

  日期：2006.3

  A series of new chiral imidazolinium salts were prepared and tested as catalysts. It was possible to show that bis-imidazolinium salts had a higher reactivity than mono-imidazolium salts. In addition a chiral discrimination of the bis-imidazolinium salts with the potassium salt of racemic Mosher's acid wits proven by NMR studies. (c) 2006 Elsevier Ltd. All rights reserved.