(E,2S,3R,4S)-3-[tert-butyl(dimethyl)silyl]oxy-8-(methoxymethoxy)-2,4,6-trimethyloct-6-enal | 217640-14-7

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: (E,2S,3R,4S)-3-[tert-butyl(dimethyl)silyl]oxy-8-(methoxymethoxy)-2,4,6-trimethyloct-6-enal
• CAS: 217640-14-7
• 化学式: C₁₉H₃₈O₄Si
• 分子量: 358.594
• InChiKey: QSGJQHGYZADCAV-OSIXJXAGSA-N

物化性质

• 沸点：
  394.9±42.0 °C(Predicted)
• 密度：
  0.922±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  24
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.84
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (E,2S,3R,4S)-3-[tert-butyl(dimethyl)silyl]oxy-8-(methoxymethoxy)-2,4,6-trimethyloct-6-enal 在 吡啶 、 咪唑 、 2,6-二甲基吡啶 、 manganese(IV) oxide 、 sodium chlorite 、 sodium dihydrogenphosphate 、 lithium aluminium tetrahydride 、 二甲基溴化硼 、 四溴化碳 、 三氟甲磺酸二丁硼 、 双氧水 、 三甲基铝 、 二异丁基氢化铝 、 dimsyl lithium 、 戴斯-马丁氧化剂 、 氟化氢吡啶 、 三乙胺 、 三苯基膦 作用下， 以 四氢呋喃 、 乙醚 、 二氯甲烷 、 甲苯 、 乙腈 、 苯 为溶剂， 生成 来普霉素B
  参考文献：
  名称：

  Absolute stereostructure and total synthesis of leptomycin B

  摘要：

  The absolute stereostructure of leptomycin B, an antitumor antibiotic and inhibitor of nuclear protein export, was firstly presumed as 1 having 4S, 5R, 10R, 16R, 18S, 19R, 20S on the basis of NMR comparison with callystatin A (2) and then 1 was asymmetrically synthesized. The synthesized leptomycin B (I) was found identical with the authentic sample in HPLC and CD comparison as well as in other respects. This structural elucidation of the absolute stereostructure and total synthesis are the first example;among the leptomycin family as Streptomyces metabolites. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)01809-7
• 作为产物：
  描述：

  (4S)-3-[(E,2S,3R,4S)-3-hydroxy-8-(methoxymethoxy)-2,4,6-trimethyloct-6-enoyl]-4-propan-2-yl-1,3-oxazolidin-2-one 在 2,6-二甲基吡啶 、 三甲基铝 、 二异丁基氢化铝 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 (E,2S,3R,4S)-3-[tert-butyl(dimethyl)silyl]oxy-8-(methoxymethoxy)-2,4,6-trimethyloct-6-enal
  参考文献：
  名称：

  Absolute stereostructure and total synthesis of leptomycin B

  摘要：

  The absolute stereostructure of leptomycin B, an antitumor antibiotic and inhibitor of nuclear protein export, was firstly presumed as 1 having 4S, 5R, 10R, 16R, 18S, 19R, 20S on the basis of NMR comparison with callystatin A (2) and then 1 was asymmetrically synthesized. The synthesized leptomycin B (I) was found identical with the authentic sample in HPLC and CD comparison as well as in other respects. This structural elucidation of the absolute stereostructure and total synthesis are the first example;among the leptomycin family as Streptomyces metabolites. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)01809-7

文献信息

• Absolute stereostructure and total synthesis of leptomycin B
  作者：Motomasa Kobayashi、Weiqi Wang、Yasuhiro Tsutsui、Masanori Sugimoto、Nobutoshi Murakami

  DOI：10.1016/s0040-4039(98)01809-7

  日期：1998.11

  The absolute stereostructure of leptomycin B, an antitumor antibiotic and inhibitor of nuclear protein export, was firstly presumed as 1 having 4S, 5R, 10R, 16R, 18S, 19R, 20S on the basis of NMR comparison with callystatin A (2) and then 1 was asymmetrically synthesized. The synthesized leptomycin B (I) was found identical with the authentic sample in HPLC and CD comparison as well as in other respects. This structural elucidation of the absolute stereostructure and total synthesis are the first example;among the leptomycin family as Streptomyces metabolites. (C) 1998 Elsevier Science Ltd. All rights reserved.