(6-Methoxy-[1,2,5]oxadiazolo[3,4-b]pyrazin-5-yl)-p-tolyl-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (6-Methoxy-[1,2,5]oxadiazolo[3,4-b]pyrazin-5-yl)-p-tolyl-amine
• 英文别名: 5-methoxy-N-(4-methylphenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazin-6-amine
• 化学式: C₁₂H₁₁N₅O₂
• mdl: MFCD00501897
• 分子量: 257.25
• InChiKey: CPMIZNBZKBZBGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  86
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• IMIDAZOPYRIDINES USEFUL AS MITOCHONDRIAL UNCOUPLERS
  申请人：Virginia Tech Intellectual Properties, Inc.

  公开号：EP3781567A1

  公开（公告）日：2021-02-24
• OXADIAZOLOPYRAZINES AND OXADIAZOLOPYRIDINES USEFUL AS MITOCHONDRIAL UNCOUPLERS
  申请人：Virginia Tech Intellectual Properties, Inc.

  公开号：US20210253594A1

  公开（公告）日：2021-08-19

  The disclosure provide compounds of Formula I and the pharmaceutically acceptable salts thereof. The variables, R 1 , R 2 , R 3 , X 1 , X 2 , and Z are defined herein. Certain compounds of Formula I act as selective mitochondrial protonophore uncouplers that do not affect the plasma membrane potential. Compounds and salts of Formula I are useful for treating or decreasing the risk of conditions responsive to mitochondrial uncoupling, such as cancer, obesity, type II diabetes, fatty liver disease, insulin resistance, Parkinson's disease, ischemia reperfusion injury, heart failure, non-alcoholic fatty liver disease (NALFD), and non-alcoholic steatohepatitis (NASH). Because mitochondrial uncouplers decrease the production of reactive oxygen species (ROS), which are known to contribute to age-related cell damage, compounds of Formula I are useful for increasing lifespan. Compounds and salts of Formula I are also useful for regulating glucose homeostasis or insulin action in a patient.
• [EN] OXADIAZOLOPYRAZINES AND OXADIAZOLOPYRIDINES USEFUL AS MITOCHONDRIAL UNCOUPLERS<br/>[FR] OXADIAZOLOPYRAZINES ET OXADIAZOLOPYRIDINES UTILISÉES COMME DÉCOUPLANTS MITOCHONDRIAUX
  申请人：VIRGINIA TECH INTELLECTUAL PROPERTIES INC

  公开号：WO2019204813A1

  公开（公告）日：2019-10-24

  The disclosure provide compounds of Formula I and the pharmaceutically acceptable salts thereof. The variables, R1, R2, R3, X1, X2, and Z are defined herein. Certain compounds of Formula I act as selective mitochondrial protonophore uncouplers that do not affect the plasma membrane potential. Compounds and salts of Formula I are useful for treating or decreasing the risk of conditions responsive to mitochondrial uncoupling, such as cancer, obesity, type II diabetes, fatty liver disease, insulin resistance, Parkinson's disease, ischemia reperfusion injury, heart failure, non-alcoholic fatty liver disease (NALFD), and non-alcoholic steatohepatitis (NASH). Because mitochondrial uncouplers decrease the production of reactive oxygen species (ROS), which are known to contribute to age-related cell damage, compounds of Formula I are useful for increasing lifespan. Compounds and salts of Formula I are also useful for regulating glucose homeostasis or insulin action in a patient.
• [EN] IMIDAZOPYRIDINES USEFUL AS MITOCHONDRIAL UNCOUPLERS<br/>[FR] IMIDAZOPYRIDINES UTILES EN TANT QUE DÉCOUPLEURS MITOCHONDRIAUX
  申请人：VIRGINIA TECH INTELLECTUAL PROPERTIES INC

  公开号：WO2019204816A1

  公开（公告）日：2019-10-24

  The disclosure provides compounds of Formula ( I-A ) and ( I-B) and the pharmaceutically acceptable salts thereof. The variables, R, R2, R3, X1, X2, X3, Y1, Y, and Z are defined herein. Certain compounds of Formula ( I-A) and (I-B) act as selective mitochondrial protonophore uncouplers that do not affect plasma membrane potential. These compounds are useful for treating or decreasing the risk of conditions responsive to mitochondrial uncoupling, such as cancer, obesity, type II diabetes, fatty liver disease, insulin resistance, Parkinson's disease, ischemia reperfusion injury, heart failure, non-alcoholic fatty liver disease (NALFD), and non-alcoholic steatohepatitis (NASH). Because mitochondrial uncouplers decrease the production of reactive oxygen species (ROS), which are known to contribute to age-related cell damage, the compounds are useful for increasing lifespan. Compounds and salts of Formula( I-A ) and (I-B) are also useful for regulating glucose homeostasis or insulin action in a patient.