2-{[(1-methyl-1H-benzimidazol-2-yl)methyl]sulfanyl}-1-phenyl-1H-benzimidazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-{[(1-methyl-1H-benzimidazol-2-yl)methyl]sulfanyl}-1-phenyl-1H-benzimidazole
• 英文别名: 1-methyl-2-[(1-phenylbenzimidazol-2-yl)sulfanylmethyl]benzimidazole
• 化学式: C₂₂H₁₈N₄S
• mdl: MFCD02182359
• 分子量: 370.5
• InChiKey: ZCTWFOXVRMTYHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  60.9
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Activators of protein phosphatase 5
  申请人：Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE)

  公开号：EP2878677A1

  公开（公告）日：2015-06-03

  The present invention relates to compounds that show a positive result in a phosphatase activation assay with protein phosphatase 5 according to the invention, to compounds that bind in an in vitro binding assay to a certain region of the amino acid sequence of protein phosphatase 5, as well as to compounds that show a positive result in a phosphatase activation assay with protein phosphatase 5 according to the invention and bind in an in vitro binding assay to a certain region of the amino acid sequence of protein phosphatase 5. The present invention also relates to pharmaceutical compositions comprising one or more of such compounds, to methods of using such a compound, and to methods of screening for compounds that activate protein phosphatase 5.

  本发明涉及在根据本发明的蛋白磷酸酶5的磷酸酶活化试验中显示阳性结果的化合物，涉及在体外结合试验中与蛋白磷酸酶5的氨基酸序列的特定区域结合的化合物，以及涉及在根据本发明的蛋白磷酸酶5的磷酸酶活化试验中显示阳性结果并在体外结合试验中与蛋白磷酸酶5的氨基酸序列的特定区域结合的化合物。本发明还涉及包含一种或多种此类化合物的药物组合物、使用此类化合物的方法以及筛选激活蛋白磷酸酶5的化合物的方法。