<2-Methyl-pyrimidyl-(5)>-essigsaeure-ethylester | 2134-40-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: <2-Methyl-pyrimidyl-(5)>-essigsaeure-ethylester
• 英文别名: 2-Methyl-5-ethoxycarbonylmethyl-pyrimidin；2-Methyl-pyrimidin-5-essigsaeure-ethylester；(2-methyl-pyrimidin-5-yl)-acetic acid ethyl ester；Ethyl 2-methyl-5-pyrimidineacetate；ethyl 2-(2-methylpyrimidin-5-yl)acetate
• CAS: 2134-40-9
• 化学式: C₉H₁₂N₂O₂
• 分子量: 180.206
• InChiKey: ZBHFICQWNKECFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  52.1
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• VITAMIN D-LIKE COMPOUND
  申请人：CHUGAI SEIYAKU KABUSHIKI KAISHA

  公开号：EP1894911A1

  公开（公告）日：2008-03-05

  The present invention provides a compound represented by the following general formula (I): or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing such a compound, and the like. The compound or a pharmaceutically acceptable salt thereof, the pharmaceutical composition containing such a compound, or the like is useful as a medicine or the like for therapy of benign prostatic hyperplasia, cancer, osteoporosis, psoriasis, secondary hyperparathyroidism, chronic glomerulonephritis, lupus nephritis and/or diabetic nephropathy and the like.

  本发明提供了一种由下列通式（I）表示的化合物： 或其药用的可接受盐，包含该化合物的药物组合物等。该化合物或其药用的可接受盐，包含该化合物的药物组合物等，用作治疗良性前列腺增生、癌症、骨质疏松症、银屑病、继发性甲状旁腺功能亢进、慢性肾小球肾炎、狼疮性肾炎和/或糖尿病性肾病等的药物等。