N-[4-Chloro-3-(trifluoromethyl)phenyl]-2,6-dimethoxybenzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[4-Chloro-3-(trifluoromethyl)phenyl]-2,6-dimethoxybenzamide
• 化学式: C₁₆H₁₃ClF₃NO₃
• mdl: MFCD00128780
• 分子量: 359.732
• InChiKey: KSTUPMBQFYRFPW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2,6-二甲氧基苯甲酸 、 2-氯-5-氨基三氟甲苯 在 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 以60%的产率得到N-[4-Chloro-3-(trifluoromethyl)phenyl]-2,6-dimethoxybenzamide
  参考文献：
  名称：

  WO2020163731A5

  摘要：

  公开号：

  WO2020163731A5

文献信息

• HISTONE ACETYLTRANSFERASE MODULATORS AND COMPOSITIONS AND USES THEREOF
  申请人：The Trustees of Columbia University in the City of New York

  公开号：US20220127232A1

  公开（公告）日：2022-04-28

  Compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a compound that modulates HAT to a subject.
• [EN] HISTONE ACETYLTRANSFERASE MODULATORS AND COMPOSITIONS AND USES THEREOF<br/>[FR] MODULATEURS D'HISTONE ACÉTYLTRANSFÉRASE ET COMPOSITIONS ET UTILISATIONS ASSOCIÉES
  申请人：UNIV COLUMBIA

  公开号：WO2020163731A1

  公开（公告）日：2020-08-13

  Compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a compound that modulates HAT to a subject.
• WO2020163731A5
  申请人：——

  公开号：WO2020163731A5

  公开（公告）日：2023-02-15