N-(amino((4-methylquinazolin-2-yl)amino)methylene)acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-(amino((4-methylquinazolin-2-yl)amino)methylene)acetamide
• 英文别名: Guanidine, 2-acetyl-1-(4-methyl-2-quinazolinyl)-；N-[(E)-N'-(4-methylquinazolin-2-yl)carbamimidoyl]acetamide
• 化学式: C₁₂H₁₃N₅O
• 分子量: 243.268
• InChiKey: RFIOQGIZEYSGJK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  93.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-(4-甲基喹唑啉-2-基)胍 、 乙酸酐 以 二甲基亚砜 为溶剂， 以10 %的产率得到N-(amino((4-methylquinazolin-2-yl)amino)methylene)acetamide
  参考文献：
  名称：

  [EN] COMPOUNDS
  [FR] COMPOSÉS

  摘要：

  Disclosed are compounds of the formula (I), or a tautomeric form thereof, or a pharmaceutically acceptable salt or N-oxide thereof: (I) wherein R1, R2, R3, R4, R5, n, m, and x are as defined herein. Compounds of the invention may be suitable for use in treating diseases/conditions which are associated with PTC mutations. Also disclosed are pharmaceutical compositions comprising the compounds; and the compounds for use in treating conditions or disorders which are associated with PTC mutations in a subject.

  公开号：

  WO2024003535A2