Dihydronormorphine, 3,6-dideoxy-

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: Dihydronormorphine, 3,6-dideoxy-
• 英文别名: 1,2,3,4,4a,5,6,7,7a,13-decahydro-4,12-methanobenzofuro[3,2-e]isoquinoline
• 化学式: C₁₆H₁₉NO
• 分子量: 241.33
• InChiKey: QONGLMDHKNFCDX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Preparation of Saturated Ketone Morphinan Compounds Having Low Metal Content
  申请人：Jiang Tao

  公开号：US20110269963A1

  公开（公告）日：2011-11-03

  The present invention provides processes for the preparation of saturated ketone morphinan compounds from a morphinan comprising an allyl alcohol ring moiety, wherein the final product has a low metal content. In particular, the invention provides processes that utilize isomerization reactions catalyzed by transition metal catalysts and the subsequent removal of the transition metal using metal scavengers.

  本发明提供了一种从含有烯丙醇环基团的吗啡骨架制备饱和酮吗啡类化合物的方法，其中最终产品的金属含量较低。具体而言，该发明提供了利用过渡金属催化的异构化反应和随后利用金属捕集剂去除过渡金属的方法。
• Preparation of Saturated Ketone Morphinan Compounds by Catalytic Isomerization
  申请人：Wang Peter X.

  公开号：US20100261904A1

  公开（公告）日：2010-10-14

  The present invention provides processes for the preparation of saturated ketone morphinan compounds by catalytic isomerization. In particular, the invention provides processes for the conversion of a morphinan comprising an allyl alcohol ring moiety into a morphinan comprising a saturated ketone ring moiety by an isomerization reaction catalyzed by an allyl-transition metal catalyst.

  本发明提供了通过催化异构化制备饱和酮吗啡类化合物的方法。具体而言，该发明提供了一种将含有烯丙醇环基团的吗啡类化合物转化为含有饱和酮环基团的吗啡类化合物的方法，该方法通过由烯丙基过渡金属催化剂催化的异构化反应实现。
• Processes for the synthesis of opiates alkaloids with reduced impurity formation
  申请人：Orr Brian

  公开号：US20100081813A1

  公开（公告）日：2010-04-01

  The invention provides processes for the production of opiate alkaloids. In particular, the present invention provides processes for the formation of opiate alkaloids that minimizes the formation of impurities.

  该发明提供了鸦片生物碱生产的工艺。具体来说，本发明提供了一种形成鸦片生物碱的工艺，可以最大程度地减少杂质的形成。
• Processes for synthesis of opiate alkaloid derivatives
  申请人：Mannino Anthony

  公开号：US20100081816A1

  公开（公告）日：2010-04-01

  The present invention provides processes for the synthesis of opiate alkaloids. In particular, the opiate alkaloids produced by the process of the invention are typically intermediate compounds that may be utilized to produce a variety of biologically active alkaloids including buprenorphine and diprenorphine.

  本发明提供了阿片类生物碱的合成过程。具体来说，本发明的过程产生的阿片类生物碱通常是中间化合物，可用于生产各种具有生物活性的生物碱，包括丁丙诺啡和地丙诺啡。
• 3-Oxy-Hydromorphone Derivatives
  申请人：Cantrell Gary L.

  公开号：US20110015398A1

  公开（公告）日：2011-01-20

  The present invention provides 3-oxy-hydromorphone derivatives, and in particular, 3-ester, 3-carbonate, and 3-sulfonate derivatives of hydromorphone.

  本发明提供了3-氧基羟吗啡衍生物，特别是羟吗啡的3-酯、3-碳酸酯和3-磺酸酯衍生物。