2-phenyl-tetrahydro-isoindole-1,3,5-trione | 56229-74-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 2-phenyl-tetrahydro-isoindole-1,3,5-trione
• 英文别名: N-phenyl-4-oxocyclohexane-1,2-dicarboximide；Isoindole-1,3,5-trione, perhydro-2-phenyl-；2-phenyl-4,6,7,7a-tetrahydro-3aH-isoindole-1,3,5-trione
• CAS: 56229-74-4
• 化学式: C₁₄H₁₃NO₃
• 分子量: 243.262
• InChiKey: CQHXOMPXELMNFT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  54.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-phenyl-tetrahydro-isoindole-1,3,5-trione 、 4-甲氧基-2-甲基苯肼.盐酸盐 生成 N-phenyl-6-methoxy-8-methyl-1,2,3,4-tetrahydro-carbazole-3,4-dicarboximide
  参考文献：
  名称：

  Isoindole derivatives and salts thereof and antitumor agent comprising

  摘要：

  由一般式[1]表示的新型异吲哚衍生物或其盐：##STR1##具有优异的抗肿瘤活性和低毒性。

  公开号：

  US05166204A1
• 作为产物：
  描述：

  1-(1,3-Dioxo-2-phenyl-2,3,3a,4,7,7a-hexahydro-1H-isoindol-5-yl)-pyridinium; bromide 在 盐酸 、 sodium tetrahydroborate 作用下， 生成 2-phenyl-tetrahydro-isoindole-1,3,5-trione
  参考文献：
  名称：

  1-(2-Butadienyl)pyridinium Bromide, A Novel Diene in Diels-Alder Reactions

  摘要：

  1-(3-Sulfolenyl)pyridinium bromide (4) serves as the stable precursor for a novel, positively charged diene 6 which undergoes [4 + 2] cycloadditions with a number of electron-poor dienophiles.

  DOI：

  10.1021/jo00095a006

文献信息

• A polymer-supported silyl triflate and subsequent functionalization: synthesis and solid-phase Diels-Alder reactions of silyloxydienes
  作者：Eric M. Smith

  DOI：10.1016/s0040-4039(99)00440-2

  日期：1999.4

  The synthesis of a polymer-supported silyl triflate and subsequent functionalization with enolizable α, β-unsaturated aldehydes and ketones to form silyloxydienes is reported herein. This novel route is ideal for the generation of substrates for solid-phase Diels-Alder reactions. The silyl triflate and diene synthesis, subsequent [4 + 2] cycloadditions, and electrophilic cleavage are described.Figure

  本文报道了聚合物负载的三氟甲磺酸硅烷基酯的合成和随后用可烯丙基的α，β-不饱和醛和酮官能化以形成甲硅烷基氧二烯。这种新颖的方法非常适合生成用于固相Diels-Alder反应的底物。描述了三氟甲磺酸硅酯和二烯的合成，随后的[4 + 2]环加成反应以及亲电裂解。图选项
• [EN] FUSED CYCLIC SUCCINIMIDE COMPOUNDS AND ANALOGS THEREOF, MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION<br/>[FR] COMPOSES D'IMIDES SUCCINIQUES CYCLIQUES ACCOLES ET LEURS ANALOGUES, MODULATEURS DE LA FONCTION DU RECEPTEUR D'HORMONES NUCLEAIRES
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2002067939A1

  公开（公告）日：2002-09-06

  Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.

  融合环化合物，使用这种化合物治疗与核激素受体相关的疾病，如癌症和免疫紊乱的方法，以及包含这种化合物的制药组合物。
• Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
  申请人：——

  公开号：US20040087548A1

  公开（公告）日：2004-05-06

  Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.

  融合的环状化合物，使用这种化合物治疗与核激素受体相关的疾病，如癌症和免疫紊乱的方法，以及包含这种化合物的制药组合物。
• Synthesis and Diels−Alder Reactions of Butadienylpyridinium Bromides
  作者：Shwu-Jiuan Lee、Chiou-Bih Tzeng、Yung-I Liu、Chao-Jung Chien、Ta-shue Chou

  DOI：10.1021/jo971181z

  日期：1997.10.1

  1-(3-Sulfolen-3-yl)pyridinium bromide (5) and 1-(3-methyl-2-sulfolen-4-yl)pyridinium bromide (35) have been prepared and served as the stable precursors for the cation-substituted dienes 6a and 32a, respectively. Compounds 6a and 32a are reactive dienes in the Diels-Alder reactions with a number of electron-poor dienophiles. Some [4 + 2] cycloadditions of 66 and 32a can take place in water.
• FUSED CYCLIC SUCCINIMIDE COMPOUNDS AND ANALOGS THEREOF, MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION
  申请人：Bristol-Myers Squibb Company

  公开号：EP1379249A1

  公开（公告）日：2004-01-14