allyl 5-methyl-7-(2-furyl)-8-cyano-2,3,4,7-tetrahydrothiazolo[3,2-a]pyridine-6-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: allyl 5-methyl-7-(2-furyl)-8-cyano-2,3,4,7-tetrahydrothiazolo[3,2-a]pyridine-6-carboxylate
• 英文别名: 7H-Thiazolo[3,2-a]pyridine-6-carboxylic acid, 2,3-dihydro-8-cyano-7-(2-furyl)-5-methyl-, allyl ester；prop-2-enyl 8-cyano-7-(furan-2-yl)-5-methyl-3,7-dihydro-2H-[1,3]thiazolo[3,2-a]pyridine-6-carboxylate
• 化学式: C₁₇H₁₆N₂O₃S
• 分子量: 328.392
• InChiKey: SHZATTGRCNSHFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  91.8
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-Butenoic acid, 3-(4-morpholinyl)-, 2-propenyl ester, (Z)- 在 吗啉 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 生成 allyl 5-methyl-7-(2-furyl)-8-cyano-2,3,4,7-tetrahydrothiazolo[3,2-a]pyridine-6-carboxylate
  参考文献：
  名称：

  New synthetic method for functionally substituted morpholinium 1,4-dihydropyridine-2-thiolates and their derivatives

  摘要：

  By condensation of aromatic aldehydes with cyanothioacetamide and enamines of 1,3-dicarbonyl compounds functionally substituted morpholinium 1,4-dihydropyridine-2-thiolates were obtained applied to the synthesis of 2-alkylsulfanyl-1,4-dihydropyridines, 1,4-dillydrothieno[2,3-b]-pyridines, and 2,3,4,7-tetra-hydrothiazolo[3,2-a]pyridine.

  DOI：

  10.1134/s1070428007020194

文献信息

• New synthetic method for functionally substituted morpholinium 1,4-dihydropyridine-2-thiolates and their derivatives
  作者：V. D. Dyachenko

  DOI：10.1134/s1070428007020194

  日期：2007.2

  By condensation of aromatic aldehydes with cyanothioacetamide and enamines of 1,3-dicarbonyl compounds functionally substituted morpholinium 1,4-dihydropyridine-2-thiolates were obtained applied to the synthesis of 2-alkylsulfanyl-1,4-dihydropyridines, 1,4-dillydrothieno[2,3-b]-pyridines, and 2,3,4,7-tetra-hydrothiazolo[3,2-a]pyridine.