4-(4-Chloro-3-(trifluoromethyl)phenyl)pyridine | 958993-66-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-(4-Chloro-3-(trifluoromethyl)phenyl)pyridine
• 英文别名: 4-[4-chloro-3-(trifluoromethyl)phenyl]pyridine
• CAS: 958993-66-3
• 化学式: C₁₂H₇ClF₃N
• 分子量: 257.642
• InChiKey: SGGZDKAYRANKNV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (3S,4R)-1-(benzenesulfonyl)-4-[4-chloro-3-(trifluoromethyl)phenyl]-4-methoxypiperidin-3-ol 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 溶剂黄146 为溶剂， 以70%的产率得到4-(4-Chloro-3-(trifluoromethyl)phenyl)pyridine
  参考文献：
  名称：

  Selenium dioxide-mediated methoxyhydroxylation of cyclic arylolefin

  摘要：

  Selenium dioxide-mediated methoxyhydroxylation of cyclic arylolefin with the modest yields is described. This facile strategy was also used to synthesize several 4-arylpyridines, 3-hydroxy-4-arylpyridines, and 3,4-diarylpyridines. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.01.020

文献信息

• Selenium dioxide-mediated methoxyhydroxylation of cyclic arylolefin
  作者：Meng-Yang Chang、Chung-Han Lin、Yeh-Long Chen

  DOI：10.1016/j.tetlet.2010.01.020

  日期：2010.3

  Selenium dioxide-mediated methoxyhydroxylation of cyclic arylolefin with the modest yields is described. This facile strategy was also used to synthesize several 4-arylpyridines, 3-hydroxy-4-arylpyridines, and 3,4-diarylpyridines. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.