2-(3-Iodo-phenyl)-1H-phenanthro[9,10-d]imidazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-(3-Iodo-phenyl)-1H-phenanthro[9,10-d]imidazole
• 英文别名: 2-(3-iodophenyl)-1H-phenanthro[9,10-d]imidazole
• 化学式: C₂₁H₁₃IN₂
• 分子量: 420.2
• InChiKey: RLWXQQKMTXXSQN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] ARYL IMIDAZOLES AND THEIR USE AS ANTI-CANCER AGENTS<br/>[FR] IMIDAZOLES D'ARYLE ET LEUR UTILISATION COMME AGENTS ANTICANCEREUX
  申请人：LORUS THERAPEUTICS INC

  公开号：WO2005047266A1

  公开（公告）日：2005-05-26

  Therapeutically effective 2,4,5-trisubstituted imidazole compounds are provided. Also provided are methods -of preparing the compounds and pharmaceutical compositions comprising the compounds alone or in combination with other agents. The present invention further provides for the use of the compounds as anti-cancer agents; wherein: R1 is aryl, substituted aryl, heterocycle, substituted heterocycle, heteroaryl, substituted hetéroaryl or amino; R2 and R3 are independently aryl, substituted aryl, heterocycle, heteroaryl, substituted heterocycle, or substituted heteroaryl or R2 and R3 when taken together along with the carbon atoms they are attached to, form aryl or substituted aryl, and R4 is hydrogen, halogen, hydroxyl, thiol, lower alkyl, substituted lower alkyl, lower alkenyl, substituted lower alkenyl, lower alkynyl, substituted lower alkynyl, alkylalkenyl, alkyl alkynyl, alkoxy, alkyithio, aryl, aryloxy, amino, amido, carboxyl, aryl, substituted aryl, heterocycle, heteroaryl, substituted heterocycle, heteroalkyl, cycloalkyl, substituted cycloalkyl, alkylcycloalkyl, alkylcyclobeteroalkyl, nitro, cyano or -S(O)o.2R wherein R is alkyl, substituted alkyl, aryl, substituted aryl, heterocycle, beteroaryl, substituted heterocycle, or substituted heteroaryl.

  提供了具有治疗效果的2,4,5-三取代咪唑化合物。还提供了制备这些化合物的方法以及包含这些化合物单独或与其他药剂组合的药物组合物。本发明进一步提供了将这些化合物用作抗癌剂的用途；其中：R1为芳基，取代芳基，杂环，取代杂环，杂芳基，取代杂芳基或氨基；R2和R3独立地为芳基，取代芳基，杂环，杂芳基，取代杂环，或取代杂芳基，或者R2和R3当结合在一起时与它们连接的碳原子形成芳基或取代芳基，而R4为氢，卤素，羟基，硫醇，低烷基，取代低烷基，低烯基，取代低烯基，低炔基，取代低炔基，烷基烯基，烷基炔基，烷氧基，烷硫基，芳基，芳氧基，氨基，酰胺基，羧基，芳基，取代芳基，杂环，杂芳基，取代杂环，杂烷基，环烷基，取代环烷基，烷基环烷基，烷基环杂烷基，硝基，氰基或-S(O)o.2R，其中R为烷基，取代烷基，芳基，取代芳基，杂环，杂芳基，取代杂环，或取代杂芳基。
• Aryl imidazoles and their use as anti-cancer agents
  申请人：Aptose Biosciences Inc.

  公开号：US10080739B2

  公开（公告）日：2018-09-25

  Therapeutically effective 2,4,5-trisubstituted imidazole compounds are provided. Also provided are methods of preparing the compounds and pharmaceutical compositions comprising the compounds alone or in combination with other agents. The present invention further provides for the use of the compounds as anti-cancer agents; wherein: R1 is aryl, substituted aryl, heterocycle, substituted heterocycle, heteroaryl, substituted heteroaryl or amino; R2 and R3 are independently aryl, substituted aryl, heterocycle, heteroaryl, substituted heterocycle, or substituted heteroaryl or R2 and R3 when taken together along with the carbon atoms they are attached to, form aryl or substituted aryl, and R4 is hydrogen, halogen, hydroxyl, thiol, lower alkyl, substituted lower alkyl, lower alkenyl, substituted lower alkenyl, lower alkynyl, substituted lower alkynyl, alkylalkenyl, alkyl alkynyl, alkoxy, alkylthio, aryl, aryloxy, amino, amido, carboxyl, aryl, substituted aryl, heterocycle, heteroaryl, substituted heterocycle, heteroalkyl, cycloalkyl, substituted cycloalkyl, alkylcycloalkyl, alkylcycloheteroalkyl, nitro, cyano or —S(O)o.2R wherein R is alkyl, substituted alkyl, aryl, substituted aryl, heterocycle, heteroaryl, substituted heterocycle, or substituted heteroaryl.

  提供了治疗有效的 2,4,5-三取代咪唑化合物。本发明还提供了制备这些化合物的方法以及包含这些化合物的药物组合物，这些化合物可单独使用，也可与其他药物组合使用。本发明进一步提供了化合物作为抗癌剂的用途；其中：R1 是芳基、取代的芳基、杂环、取代的杂环、杂芳基、取代的杂芳基或氨基；R2 和 R3 独立地是芳基、取代的芳基、杂环、杂芳基、取代的杂环或取代的杂芳基，或 R2 和 R3 与它们所连接的碳原子一起形成芳基或取代的芳基，以及 R4 是氢、卤素、羟基、硫醇、低级烷基、取代的低级烷基、低级烯基取代的低级烯基、低级炔基、取代的低级炔基、烷基烯基、烷基炔基、烷氧基、烷硫基、芳基、芳氧基、氨基、酰胺基、羧基、芳基、取代的芳基、杂环基、杂芳基、取代的杂环基、杂烷基、环烷基、取代的环烷基、烷基环烷基、烷基环杂环烷基、硝基、氰基或 -S(O)o。2其中 R 是烷基、取代的烷基、芳基、取代的芳基、杂环、杂芳基、取代的杂环或取代的杂芳基。
• ARYL IMIDAZOLES AND THEIR USE AS ANTI-CANCER AGENTS
  申请人：Lorus Therapeutics Inc.

  公开号：EP1692113A1

  公开（公告）日：2006-08-23
• US8969372B2
  申请人：——

  公开号：US8969372B2

  公开（公告）日：2015-03-03