(A+/-)-trans-2,5-dimethoxy-tetrahydro-furan

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢呋喃
• 英文名称: (A+/-)-trans-2,5-dimethoxy-tetrahydro-furan
• 英文别名: (2R,5R)-2,5-dimethoxyoxolane
• 化学式: C₆H₁₂O₃
• 分子量: 132.16
• InChiKey: GFISDBXSWQMOND-PHDIDXHHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• A method for resolving optical isomers
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP0970936A1

  公开（公告）日：2000-01-12

  A method for resolving optical isomers, in which a discriminating liquid consisting of an discriminating agent capable of discriminating optical isomers and a diluent is brought into contact with a mixture containing said optical isomers in counter current, to resolve the optical isomers by adsorption separation, distillation separation, absorption separation or membrane separation, and is recovered at an optical isomer content of 5 wt% or less for recycled use is characterized by satisfying one or more of the following conditions: (a) The dielectric constant of the diluent is 30 or less and the viscosity of the discriminating liquid is 0.2 Pa·s or less at the temperature of the resolving operation. (b) The discriminating agent contained has an effect of splitting the 1H or 13C-NMR spectrum peak of the optical isomers when added and the diluent contained has a dielectric constant equal to or lower than the dielectric constant of the measuring solvent at the time of measuring the 1H or 13C-NMR spectrum. (c) The boiling point of at least one compound of the discriminating agent at the pressure of resolving operation is higher than the boiling point of at least one compound of the diluent at the pressure of resolving operation. (d) The boiling point of at least one compound of the diluent at the pressure of resolving operation is higher than the boiling point of the optical isomers to be resolved, at the pressure of resolving operation by 10°C or more. (e) The concentration of the discriminating agent in the discriminating liquid is 10 wt% or more.

  一种分辨光学异构体的方法，在该方法中，由能够分辨光学异构体的分辨剂和稀释剂组成的分辨液与含有所述光学异构体的混合物逆流接触，通过吸附分离、蒸馏分离、吸收分离或膜分离来分辨光学异构体，并以 5 wt% 或更低的光学异构体含量回收光学异构体以供循环使用，其特征在于满足以下一个或多个条件： (a) 在分辨操作温度下，稀释剂的介电常数为 30 或以下，分辨液的粘度为 0.2 Pa-s 或以下。 (b) 所含鉴别剂在加入时具有分裂光学异构体的 1H 或 13C-NMR 光谱峰的效果，所含稀释剂的介电常数等于或低于测量 1H 或 13C-NMR 光谱时测量溶剂的介电常数。 (c) 至少一种鉴别剂化合物在解析操作压力下的沸点高于至少一种稀释剂化合物在解析操作压力下的沸点。 (d) 至少一种稀释剂化合物在解析操作压力下的沸点比待解析光学异构体在解析操作压力下的沸点高 10°C 或以上。 (e) 鉴别液中鉴别剂的浓度为 10 wt%或以上。
• US5064944A
  申请人：——

  公开号：US5064944A

  公开（公告）日：1991-11-12
• US5154738A
  申请人：——

  公开号：US5154738A

  公开（公告）日：1992-10-13
• US6379552B1
  申请人：——

  公开号：US6379552B1

  公开（公告）日：2002-04-30