2-(3-benzyl-2-imino-2,3-dihydro-1H-benzimidazol-1-yl)-1-phenylethanol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-(3-benzyl-2-imino-2,3-dihydro-1H-benzimidazol-1-yl)-1-phenylethanol
• 英文别名: 2-(3-benzyl-2-iminobenzimidazol-1-yl)-1-phenylethanol
• 化学式: C₂₂H₂₁N₃O
• 分子量: 343.4
• InChiKey: JBLBJLSLNPIWIC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  50.6
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] COMPOUNDS FOR TREATING CANCER<br/>[FR] COMPOSÉS UTILISÉS POUR TRAITER LE CANCER
  申请人：EVOTEC AG

  公开号：WO2010067067A1

  公开（公告）日：2010-06-17

  Compounds of general formula (I): wherein R1, R2, R3, R4, R5, R6, X and Y are as defined herein are inhibitors of Bcl-2 and are useful for treating diseases characterised by abnormal cell growth and/or dysregulated apoptosis.

  通式（I）的化合物：其中R1、R2、R3、R4、R5、R6、X和Y如本文所定义，是Bcl-2的抑制剂，可用于治疗以异常细胞生长和/或失调凋亡为特征的疾病。
• [EN] BICYCLIC INHIBITORS OF CBX CHROMODOMAINS<br/>[FR] INHIBITEURS BICYCLIQUES DE CHROMODOMAINES CBX
  申请人：ICAHN SCHOOL OF MEDICINE AT MT SINAI

  公开号：WO2021061801A1

  公开（公告）日：2021-04-01

  A genus of bicyclic inhibitors of CBX chromodomains is disclosed. The compounds are of the following genus: The compounds inhibit CBX proteins and, as a consequence, they are useful for treating prostate cancer, ovarian cancer, and B-cell lymphoma.

  揭示了一种双环抑制剂CBX chromodomains的属。这些化合物属于以下属：这些化合物抑制CBX蛋白，因此它们可用于治疗前列腺癌、卵巢癌和B细胞淋巴瘤。
• COMPOUNDS FOR TREATING CANCER
  申请人：East Stephen Peter

  公开号：US20110312969A1

  公开（公告）日：2011-12-22

  Compounds of general formula (I): wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X and Y are as defined herein are inhibitors of Bcl-2 and are useful for treating diseases characterised by abnormal cell growth and/or dysregulated apoptosis.

  通式（I）的化合物：其中R1、R2、R3、R4、R5、R6、X和Y如本文所定义，是Bcl-2的抑制剂，并且对于治疗以异常细胞增殖和/或失调的细胞凋亡为特征的疾病是有用的。
• BICYCLIC INHIBITORS OF CBX CHROMODOMAINS
  申请人：Icahn School of Medicine At Mount Sinai

  公开号：US20220402880A1

  公开（公告）日：2022-12-22

  A genus of bicyclic inhibitors of CBX chromodomains is disclosed. The compounds are of the following genus: The compounds inhibit CBX proteins and, as a consequence, they are useful for treating prostate cancer, ovarian cancer, and B-cell lymphoma.
• US8759520B2
  申请人：——

  公开号：US8759520B2

  公开（公告）日：2014-06-24