β-(5-Iod-uracilyl-3)-propionsaeure | 22483-98-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: β-(5-Iod-uracilyl-3)-propionsaeure
• 英文别名: 3-(5-iodo-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-propionic acid；3-(5-iodo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanoic acid；3-(5-iodo-2,4-dioxopyrimidin-1-yl)propanoic acid
• CAS: 22483-98-3
• 化学式: C₇H₇IN₂O₄
• mdl: MFCD01471193
• 分子量: 310.048
• InChiKey: MPDRMLZJDIQAOH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.285
• 拓扑面积：
  86.7
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• SMALL MOLECULE INHIBITORS OF TLR2 SIGNALING
  申请人：University of Maryland, Baltimore

  公开号：US20180110746A1

  公开（公告）日：2018-04-26

  The present invention is drawn to therapeutics and methods of inhibiting signaling by TLR2. The invention provides a method of treating an inflammatory disease or condition in a subject comprising administering to the subject a therapeutically effective amount of a compound of the invention or salt, solvate, hydrate, prodrug, metabolite, or combination thereof.