2,2-dimethyl-N-[2-(1-methyl-1H-benzimidazol-2-yl)ethyl]propanamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2,2-dimethyl-N-[2-(1-methyl-1H-benzimidazol-2-yl)ethyl]propanamide
• 英文别名: 2,2-dimethyl-N-[2-(1-methylbenzimidazol-2-yl)ethyl]propanamide
• 化学式: C₁₅H₂₁N₃O
• 分子量: 259.35
• InChiKey: OSHMRAXZMNQWKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  46.9
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Substituted 6,5-Fused Bicyclic Heteroaryl Compounds
  申请人：Epizyme, Inc.

  公开号：US20140296283A1

  公开（公告）日：2014-10-02

  The present invention relates to azole bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

  本发明涉及杂环双环杂芳基化合物。本发明还涉及含有这些化合物的药物组合物以及通过将这些化合物和药物组合物用于需要的受试者治疗癌症的方法。本发明还涉及将这些化合物用于研究或其他非治疗目的的使用。
• Substituted 6, 5-Fused Bicyclic Heteroaryl Compounds
  申请人：EPIZYME, INC.

  公开号：US20150246916A1

  公开（公告）日：2015-09-03

  The present invention relates to azole bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

  本发明涉及杂环双环杂芳烃化合物。本发明还涉及含有这些化合物的药物组合物以及通过将这些化合物和药物组合物用于需要的受试者治疗癌症的方法。本发明还涉及将这些化合物用于研究或其他非治疗目的的用途。
• Substituted 6,5-fused bicyclic heteroaryl compounds
  申请人：Epizyme, Inc.

  公开号：US10174019B2

  公开（公告）日：2019-01-08

  The present invention relates to azole bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

  本发明涉及唑类双环杂芳基化合物。本发明还涉及含有这些化合物的药物组合物，以及通过向有需要的受试者施用这些化合物和药物组合物来治疗癌症的方法。本发明还涉及将这些化合物用于研究或其它非治疗目的。
• SUBSTITUTED 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS
  申请人：Epizyme, Inc.

  公开号：US20160326170A1

  公开（公告）日：2016-11-10

  The present invention relates to azole bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
• US9045477B2
  申请人：——

  公开号：US9045477B2

  公开（公告）日：2015-06-02