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5-乙氧基-1,3-二氢-2H-苯并咪唑-2-酮 | 39513-22-9

中文名称
5-乙氧基-1,3-二氢-2H-苯并咪唑-2-酮
中文别名
——
英文名称
5-ethoxy-1,3-dihydro-benzoimidazol-2-one
英文别名
5-ethoxy-1,3-dihydro-benzimidazol-2-one;5-Aethoxy-1,3-dihydro-benzimidazol-2-on;5-Ethoxy-2-benzimidazolinon;5-Ethoxy-benzimidazolon;5-Ethoxy-1H-benzo[d]imidazol-2(3H)-one;5-ethoxy-1,3-dihydrobenzimidazol-2-one
5-乙氧基-1,3-二氢-2H-苯并咪唑-2-酮化学式
CAS
39513-22-9
化学式
C9H10N2O2
mdl
MFCD09881091
分子量
178.191
InChiKey
NWUXEFLAKIZIGO-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    0.9
  • 重原子数:
    13
  • 可旋转键数:
    2
  • 环数:
    2.0
  • sp3杂化的碳原子比例:
    0.222
  • 拓扑面积:
    50.4
  • 氢给体数:
    2
  • 氢受体数:
    2

反应信息

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文献信息

  • BICYCLIC HETEROARYL COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN
    申请人:Global Blood Therapeutics, Inc.
    公开号:US20150259296A1
    公开(公告)日:2015-09-17
    Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.
    本文提供了适用作为血红蛋白调节剂的化合物和药物组合物,它们的制备方法和中间体,以及在治疗由血红蛋白介导的疾病和需要组织和/或细胞氧合的疾病中使用它们的方法。
  • Benzimidazolone derivatives
    申请人:——
    公开号:US20040147506A1
    公开(公告)日:2004-07-29
    This invention relates to benzimidazolone derivatives, represented by compounds of a general formula [I] 1 [in which R 1 and R 2 stand for, e.g., hydrogen atoms; R 3a , R 3b , R 4 , R 5 stand for, e.g., hydrogen atoms and alkyl groups; R 6 stands for e.g., aryl or heteroaryl groups; A ring stands for 5- to 8-membered aliphatic heterocyclic ring containing one nitrogen atom; and Z stands for carbonyl group or sulfonyl group]. The benzimidazolone derivatives of the invention exhibit antagonism to muscarinic acetylcholine receptors, and are useful as treating agent and/or prophylactic of Parkinson's disease, drug-induced parkinsonism, dystonia, akinesia, pancreatitis, bilestone/cholecystitis, biliary dyskinesia, achalasia, pain, itch, cholinergic urticaria, irritable bowel syndrome, vomiting, nausea, dizziness, Meniere's disease, motion sickness and urinary disturbance.
    本发明涉及苯并咪唑酮衍生物,其由一般式[I]中的化合物表示,其中R1和R2代表氢原子;R3a、R3b、R4、R5代表氢原子和烷基基团;R6代表芳基或杂环芳基基团;A环代表含有一个氮原子的5-至8-成员脂肪族杂环环;Z代表羰基团或磺酰基团。本发明的苯并咪唑酮衍生物表现出对肌动蛋白乙酰胆碱受体的拮抗作用,可用作帕金森病、药物诱导的帕金森综合征、肌张力障碍、运动障碍、胰腺炎、胆石/胆囊炎、胆道运动障碍、食管失弛缓症、疼痛、瘙痒、胆碱能荨麻疹、肠易激综合征、呕吐、恶心、眩晕、梅尼埃病、晕动病和尿液障碍的治疗剂和/或预防剂。
  • SUBSTITUTED IMIDAZOLIDINONE DERIVATIVES
    申请人:BANYU PHARMACEUTICAL CO., LTD.
    公开号:EP1221443A1
    公开(公告)日:2002-07-10
    This invention relates to the compounds represented by the general formula [I],    [in which A-D signify optionally substituted methine group(s) or nitrogen atom; E signifies oxygen or sulfur atom; signify optionally substituted mono- or bi-cyclic aliphatic nitrogen-containing heterocyclic group(s); R1 signifies lower alkenyl, lower alkynyl, cyclo(lower alkyl), lower alkanoyl, lower alkoxycarbonyl, optionally substituted lower alkyl and the like; and R2 signifies lower alkyl]. The compounds of the present invention exhibit an action to stimulate muscarinic acetylcholine receptors M4, and are useful as analgesic for diseases accompanying pain such as cancerous pain, migraine, gout, chronic rheumatism, chronic pain or neuralgia; or as agents for treating tolerance to narcotic analgesics represented by morphine, dependence on narcotic analgesics represented by morphine, itching, dementia, irritable bowel syndrome, schizophrenia, glaucoma, pollakiuria, urinary incontinence, cholelithiasis, cholecystitis, functional dyspepsia and reflux esophagitis.
    本发明涉及通式[I]所代表的化合物、 [其中 A-D 表示任选取代的甲基或氮原子;E 表示氧原子或硫原子; 表示任选取代的单环或双环脂肪族含氮杂环基团;R1 表示低级烯基、低级炔基、环(低级烷基)、低级烷酰基、低级烷氧羰基、任选取代的低级烷基等;R2 表示低级烷基]。 本发明的化合物具有刺激毒蕈碱乙酰胆碱受体 M4 的作用,可作为镇痛剂用于治疗伴随疼痛的疾病,如癌性疼痛、偏头痛、痛风、慢性风湿病、慢性疼痛或神经痛;或作为治疗对以吗啡为代表的麻醉性镇痛剂的耐受性、对以吗啡为代表的麻醉性镇痛剂的依赖性、瘙痒、痴呆、肠易激综合征、精神分裂症、青光眼、花斑尿、尿失禁、胆石症、胆囊炎、功能性消化不良和反流性食管炎的药物。
  • BENZIMIDAZOLONE DERIVATIVES
    申请人:BANYU PHARMACEUTICAL CO., LTD.
    公开号:EP1386920A1
    公开(公告)日:2004-02-04
    This invention relates to benzimidazolone derivatives, represented by compounds of a general formula [I]    [in which R1 and R2 stand for, e.g., hydrogen atoms; R3a, R3b, R4, R5 stand for, e.g., hydrogen atoms and alkyl groups; R6 stands for e.g., aryl or heteroaryl groups; A ring stands for 5- to 8-membered aliphatic heterocyclic ring containing one nitrogen atom; and Z stands for carbonyl group or sulfonyl group]. The benzimidazolone derivatives of the invention exhibit antagonism to muscarinic acetylcholine receptors, and are useful as treating agent and/or prophylactic of Parkinson's disease; drug-induced parkinsonism, dystonia, akinesia, pancreatitis, bilestone/cholecystitis, biliary dyskinesia, achalasia, pain, itch, cholinergic urticaria, irritable bowel syndrome, vomiting, nausea, dizziness, Meniere's disease, motion sickness and urinary disturbance.
    本发明涉及苯并咪唑酮衍生物,以通式[I]的化合物为代表。 [其中 R1 和 R2 代表氢原子;R3a、R3b、R4、R5 代表氢原子和烷基;R6 代表芳基或杂芳基;A 环代表含有一个氮原子的 5 至 8 元脂肪杂环;Z 代表羰基或磺酰基]。 本发明的苯并咪唑酮衍生物对毒蕈碱乙酰胆碱受体具有拮抗作用,可作为帕金森病的治疗药物和/或预防药物;药物诱发的帕金森病、肌张力障碍、运动障碍、胰腺炎、胆石症/胆囊炎、胆汁运动障碍、贲门失弛缓症、疼痛、瘙痒、胆碱能性荨麻疹、肠易激综合征、呕吐、恶心、头晕、美尼尔氏病、晕车和排尿障碍。
  • [EN] DERIVATIVE OF METHACRYLOYL-BENZIMIDAZOL-ONE (THIONE) AND USE THEREOF AS ANTI-MICROBIAL DRUG<br/>[FR] DÉRIVÉ DE MÉTHACRYLOYL-BENZIMIDAZOL-ONE (THIONE) ET SON UTILISATION EN TANT QUE MÉDICAMENT ANTIMICROBIEN
    申请人:UNIV NORTHWEST A&F
    公开号:WO2013059984A1
    公开(公告)日:2013-05-02
    本发明公开了一类新的甲基丙烯酰基苯并咪唑(硫)酮衍生物,该化合物的制备方法,以及该化合物作为抗菌药物的用途。该化合物具有如下通式(I)所示结构,式中R和Y具有如说明书所述的含义。
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