(3-methylhept-1-ynyl)benzene | 74835-52-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3-methylhept-1-ynyl)benzene
• 英文别名: 3-Methylhept-1-ynylbenzene
• CAS: 74835-52-2
• 化学式: C₁₄H₁₈
• 分子量: 186.297
• InChiKey: QBSNEGPUDUFZDV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  1-苯基庚-1-炔-3-醇 以 四氢呋喃 、 正己烷 为溶剂， 反应 0.5h， 生成 (3-methylhept-1-ynyl)benzene
  参考文献：
  名称：

  Reaction of propargylic substrates with organocopper species. Synthetic aspects

  摘要：

  DOI：

  10.1021/jo01311a037

文献信息

• Highly Chemoselective Calcium-Catalyzed Propargylic Deoxygenation
  作者：Vera J. Meyer、Meike Niggemann

  DOI：10.1002/chem.201103691

  日期：2012.4.10

  calcium‐catalyzed direct reduction of propargylic alcohols and ethers has been accomplished by using triethylsilane as a nucleophilic hydride source. At room temperature a variety of secondary propargylic alcohols was deoxygenated to the corresponding hydrocarbons in excellent yields. Furthermore, for the first time, a catalytic deoxygenation of tertiary propargylic alcohols was generally applicable. The

  通过使用三乙基硅烷作为亲核氢化物源，可以实现钙催化的炔丙醇和醚的直接还原。在室温下，各种仲炔丙醇以优异的产率脱氧为相应的烃。此外，首次普遍使用叔炔丙醇的催化脱氧。相同的方案适用于有效还原仲炔丙基和叔炔丙基甲基，苄基和烯丙基醚。含有额外的酮基，酯基或仲羟基官能团的底物在炔丙基位置具有出色的化学选择性而被还原。
• Trifluoromethyl-Radical-Mediated Carbonylation of Alkanes Leading to Ethynyl Ketones
  作者：Yoshitaka Uenoyama、Takahide Fukuyama、Keisuke Morimoto、Osamu Nobuta、Hidefumi Nagai、Ilhyong Ryu

  DOI：10.1002/hlca.200690228

  日期：2006.10

  The carbonylation of alkanes 1 under radical-reaction conditions was examined by using ethynyl triflone A as the unimolecular chain-transfer (UMCT) reagent. Good to moderate yields of ethynyl ketones 2 were prepared by means of this three-component coupling reaction. Higher CO pressures as well as lower concentrations of triflone A improved the efficiency of the reaction over the direct addition, the

  使用乙炔基三氟甲酮A作为单分子链转移（UMCT）试剂，检查了自由基反应条件下烷烃1的羰基化作用。通过这种三组分偶联反应，制备了乙炔基酮2的良好至中等的产率。与直接添加相比，较高的CO压力和较低的三氟甲酮A浓度提高了反应效率，后者导致烷基化乙炔3。与与A的反应相反，环己烷（1a）与烯丙基三酮B的反应。（＝ 2-亚甲基-3-[[（三氟甲基）磺酰基]丙酸乙酯）在CO存在下得到羰基化产物的混合物，包括由环己烷，CO和烯丙基三氟乙烯乙的两个分子各自形成的8a。
• Boryl Radical‐Mediated C−H Activation of Inactivated Alkanes for the Synthesis of Internal Alkynes
  作者：Jia‐Bin Han、Htet Htet San、Ao Guo、Long Wang、Xiang‐Ying Tang

  DOI：10.1002/adsc.202000772

  日期：2021.4.27

  radical‐mediated C−H alkynylation reaction of inactivated alkanes was described. The reaction features mild operation condition and wide substrate scope, and affords the corresponding products in moderate to good yields. Notably, The presence of 4‐cyanopyride N‐oxide was key to the success of the reaction. Cyclohexane are more easily to be functionalized in this reaction than toluene, which could be rationally

  描述了一个有趣的吡啶-硼基自由基介导的灭活烷烃的CH炔基化反应。该反应具有温和的操作条件和广泛的底物范围，并以中等至良好的产率提供了相应的产物。值得注意的是，4-氰基吡啶N-氧化物的存在是反应成功的关键。环己烷比甲苯更容易在该反应中被官能化，这可以用极性匹配原理合理地解释。
• Reaction of propargylic substrates with organocopper species. Synthetic aspects
  作者：Timothy L. Macdonald、David R. Reagan、Raymond S. Brinkmeyer

  DOI：10.1021/jo01311a037

  日期：1980.11