N-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-5-yl)methanesulfonamide | 591725-90-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-5-yl)methanesulfonamide
• 英文别名: N-(2-oxo-1,3-dihydrobenzimidazol-5-yl)methanesulfonamide
• CAS: 591725-90-5
• 化学式: C₈H₉N₃O₃S
• mdl: MFCD03785188
• 分子量: 227.244
• InChiKey: FUKQJGQHUFDOIP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.125
• 拓扑面积：
  95.7
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-5-yl)methanesulfonamide 在 N,N-二甲基苯胺 、 三氯氧磷 作用下， 生成 N-(2-chloro-3H-benzimidazol-5-yl)methanesulfonamide
  参考文献：
  名称：

  Design, syntheses, and structure–activity relationships of novel NPY Y5 receptor antagonists: 2-{3-Oxospiro[isobenzofuran-1(3H),4′-piperidin]-1′-yl}benzimidazole derivatives

  摘要：

  Design, syntheses, and structure-activity relationships of a novel class of 2-{3-oxospiro[isobenzofuran-1(3H),4'-piperidin]-1'-yl}benzimidazole NPY Y5 receptor antagonists are described. The benzimidazole structures were newly designed based on the urea linkage of our prototype Y5 receptor antagonists (2 and 3). By optimizing substituents on the benzimidazole core part of the lead compound 5a, we were able to develop a potent, orally available, and brain-penetrable Y5 selective antagonist (5k). Crown Copyright (C) 2008 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.08.018

文献信息

• Cosmetic formulations comprising diketo diphenyl pyrrolo-pyrrole pigments
  申请人：Wallquist Olof

  公开号：US20070031358A1

  公开（公告）日：2007-02-08

  The present invention relates to cosmetic formulations comprising at least one pigment of formula (I) wherein the pigments have a specific surface area (BET) of 6-200 m 2 /g, and wherein all substituents have the meanings as defined in the claims, as well as to compositions for making up the skin, both of the face and of the human body, keratinous fibers or superficial body growths, such as the nails, eyelashes, eyebrows or hair, and the lips.