(+/-)-α--propionsaeure | 13794-06-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (+/-)-α--propionsaeure
• 英文别名: 2-pentachlorophenoxy-propionic acid；2-(2,3,4,5,6-Pentachlorophenoxy)propanoic acid
• CAS: 13794-06-4
• 化学式: C₉H₅Cl₅O₃
• mdl: MFCD09042877
• 分子量: 338.402
• InChiKey: MGVBJIXMJGHUGP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-氨基青霉烷酸 、 (+/-)-α--propionsaeure 生成 6β-((Ξ)-2-pentachlorophenoxy-propionylamino)-penicillanic acid
  参考文献：
  名称：

  Derivatives of 6-Aminopenicillanic Acid. I. Partially Synthetic Penicillins Prepared from α-Aryloxyalkanoic Acids

  摘要：

  DOI：

  10.1021/ja01500a036

文献信息

• LASER-DECOMPOSABLE RESIN COMPOSITION AND PATTERN-FORMING MATERIAL USING THE SAME
  申请人：SUGASAKI Atsushi

  公开号：US20080038663A1

  公开（公告）日：2008-02-14

  A laser-decomposable resin composition contains: a compound including at least one structure selected from a carboxyl group and a carboxylic acid anhydride structure and at least one hetero atom selected from N, S and O atoms other than the structure; and a binder polymer.

  一种可激光分解的树脂组合物，包括：一种化合物，其中包括至少一种结构，所述结构从羧基和羧酸酐结构中选择至少一种，并且还包括至少一种异原子，所述异原子选自N、S和O原子以外的结构；以及一种粘合剂聚合物。
• Di(halogenated phenoxyalkanoyl)peroxides and their use as herbicides
  申请人：Kalo Laboratories, Inc.

  公开号：EP0005698A1

  公开（公告）日：1979-12-12

  Compounds are disclosed which have the formula: wherein X and X' are each chlorine, R and R' are each alkyl groups containing from 1 to 4 carbon atoms and n and n' each have a value from 1 to 5. The disclosed compounds are useful as herbicides.

  所公开的化合物具有以下式子：其中 X 和 X'各自为氯，R 和 R'各自为含有 1 至 4 个碳原子的烷基，n 和 n'各自的值为 1 至 5。 所公开的化合物可用作除草剂。
• ACETAMIDO ACETONITRILE DERIVATIVES AS INHIBITORS OF CATHEPSIN L AND/OR CATHEPSIN S
  申请人：AstraZeneca AB

  公开号：EP1155010A1

  公开（公告）日：2001-11-21
• PHOSPHOLIPID ETHER (PLE) CAR T CELL TUMOR TARGETING (CTCT) AGENTS
  申请人：Seattle Children's Hospital (dba Seattle Children's Research Institute)

  公开号：US20200087399A1

  公开（公告）日：2020-03-19

  Aspects of the invention described herein relate to synthetic compounds that are useful for targeting and labeling tumor cells so as to facilitate recognition by binding agents including Chimeric Antigen Receptor T cells (CAR T cells), which are administered to a subject by intravenous or locoregional administration. Several compositions and methods of making and using these compositions to treat or inhibit a disease in a subject are contemplated.
• METHODS AND COMPOSITIONS FOR STIMULATION OF CHIMERIC ANTIGEN RECEPTOR T CELLS WITH HAPTEN LABELLED CELLS
  申请人：Seattle Children's Hospital (dba Seattle Children's Research Institute)

  公开号：US20210317407A1

  公开（公告）日：2021-10-14

  Some embodiments of the methods and compositions provided herein relate to the use of hapten labeled cells to stimulate chimeric antigen receptor (CAR) T cells. In some embodiments, CAR T cells can include a CAR that specifically binds to a hapten. Some embodiments relate to the in vivo or in vitro stimulation CAR T cells by hapten labeled cells.