[2-(3-aminophenyl)-3H-benzimidazol-5-yl]-phenylmethanone | 296791-22-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: [2-(3-aminophenyl)-3H-benzimidazol-5-yl]-phenylmethanone
• CAS: 296791-22-5
• 化学式: C₂₀H₁₅N₃O
• 分子量: 313.4
• InChiKey: RRVMMIGOODBROK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  71.8
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• HUMAN PGC-1 PROMOTER
  申请人：YAMANOUCHI PHARMACEUTICAL CO. LTD.

  公开号：EP1284291A1

  公开（公告）日：2003-02-19

  A DNA having an hPGC-1 promoter activity; a method of screening a substance modifying this promoter activity; and drugs, which contain substances modifying the promoter activity as the active ingredient, for activating mitochondria and treating obesity and/or diabetes based on the activation of mitochondria.

  一种具有hPGC-1启动子活性的DNA；一种筛选改变这种启动子活性的物质的方法；以及含有改变启动子活性的物质作为活性成分的药物，用于激活线粒体并根据线粒体的激活治疗肥胖症和/或糖尿病。
• NOVEL SUGAR UPTAKE ACTIVATOR AND METHOD FOR SCREENING THE SAME
  申请人：Astellas Pharma Inc.

  公开号：EP1859808A1

  公开（公告）日：2007-11-28

  An activating agent of glucose uptake comprising as an active ingredient a substance having a PGC-1β function; and a method of screening for an activating agent of glucose uptake, comprising the steps of bringing a substance to be tested into contact with a promoter of a PGC-1β gene and analyzing a promoter activity of a PGC-1β gene, are disclosed. The activating agent of glucose uptake is a novel antidiabetic agent capable of promoting glucose uptake in a muscle tissue at hyperglycemia regardless of a blood insulin level.

  本发明公开了一种葡萄糖摄取激活剂，其有效成分包括一种具有 PGC-1β 功能的物质；以及一种葡萄糖摄取激活剂的筛选方法，该方法包括以下步骤：使待测物质与 PGC-1β 基因的启动子接触，并分析 PGC-1β 基因的启动子活性。葡萄糖摄取激活剂是一种新型抗糖尿病剂，能够在高血糖状态下促进肌肉组织的葡萄糖摄取，而与血液中的胰岛素水平无关。
• Human pgc-1 promoter
  申请人：——

  公开号：US20040115626A1

  公开（公告）日：2004-06-17

  A DNA having an hPGC-1 promoter activity; a method of screening a substance modifying this promoter activity; and drugs, which contain substances modifying the promoter activity as the active ingredient, for activating mitochondria and treating obesity and/or diabetes based on the activation of mitochondria.

  一种具有hPGC-1启动子活性的DNA；一种筛选改变这种启动子活性的物质的方法；以及含有改变启动子活性的物质作为活性成分的药物，用于激活线粒体并根据线粒体的激活治疗肥胖症和/或糖尿病。
• Novel Activating Agent of Glucose Uptake and a Screening Method Therefor
  申请人：Goto Masahide

  公开号：US20080070249A1

  公开（公告）日：2008-03-20

  An activating agent of glucose uptake comprising as an active ingredient a substance having a PGC-1β function; and a method of screening for an activating agent of glucose uptake, comprising the steps of bringing a substance to be tested into contact with a promoter of a PGC-1β gene and analyzing a promoter activity of a PGC-1β gene, are disclosed. The activating agent of glucose uptake is a novel antidiabetic agent capable of promoting glucose uptake in a muscle tissue at hyperglycemia regardless of a blood insulin level.