N-Phenycarbamylthiomorpholin | 29213-71-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-Phenycarbamylthiomorpholin
• 英文别名: 4-Phenylcarbamoyl-1,4-thiazan；thiomorpholine-4-carboxylic acid anilide；N-phenylthiomorpholine-4-carboxamide
• CAS: 29213-71-6
• 化学式: C₁₁H₁₄N₂OS
• mdl: MFCD03071049
• 分子量: 222.311
• InChiKey: KEZCCMZQRAUQIU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  硫代吗啉 、 异氰酸苯酯 以78%的产率得到
  参考文献：
  名称：

  ASINGER F.; SAUS A.; HARTIG J.; RASCHE P.; WILMS E., MONATSH. CHEM., 1979, 110, NO 4, 767-789

  摘要：

  DOI：

文献信息

• [EN] METHOD OF CONVERTING CARBON DIOXIDE INTO CARBONYL COMPOUNDS<br/>[FR] PROCÉDÉ DE CONVERSION DE DIOXYDE DE CARBONE EN COMPOSÉS CARBONYLE
  申请人：TRANSLATIONAL HEALTH SCIENCE AND TECH INSTITUTE

  公开号：WO2019073484A1

  公开（公告）日：2019-04-18

  The present invention provides a method for fixing carbon dioxide gas as a carbonyl compound represented by formula (3) as depicted by Figure 1 and comprising, purging of carbon dioxide in a solution of a nucleophile represented by the formula (1) in presence of a solvent at a temperature ranging from -40 Degree Celsius to 35 Degree Celsius, followed by adding a reagent at temperature ranging from -40 degree to 35 degree and thereafter adding another nucleophile represented by the formula (2) to obtain carbonyl compound represented by formula (3). The present invention can be advantageously used to obtain commercially important carbonyl compounds and clean unwanted carbon dioxide gas from the atmosphere and industrial effluents.

  本发明提供了一种固定二氧化碳气体的方法，所述方法将二氧化碳气体固定为由图1所示的化学式（3）代表的羰基化合物，包括在溶液中驱除碳酸气体，所述溶液中包含由化学式（1）代表的亲核试剂，在溶剂存在下，在温度范围从-40摄氏度到35摄氏度进行，然后在温度范围从-40摄氏度到35摄氏度添加试剂，然后添加由化学式（2）代表的另一个亲核试剂，以获得由化学式（3）代表的羰基化合物。本发明可优势用于获得商业重要的羰基化合物，并清除大气和工业废水中的不需要的二氧化碳气体。
• Amine-Induced Selective C–C Bond Cleavage of 2,2,2-Trifluoroethyl Carbonyls for the Synthesis of Ureas and Amides
  作者：Kuantao Mao、Leiyang Lv、Zhiping Li

  DOI：10.1021/acs.joc.3c00979

  日期：2023.7.21

  An efficient and selective transformation of 2,2,2-trifluoroethyl carbonyls into ureas/amides with amines is reported. This protocol allows the selective cleavage of the C–C bond of 2,2,2-trifluoroethyl carbonyls under transition metal-free and oxidant-free conditions, which is in contrast to the analogous C–F or C–CF3 bond functionalization. This reaction reveals the unexplored reactivity of 2,2,2-trifluoroethyl

  据报道，2,2,2-三氟乙基羰基与胺有效且选择性地转化为脲/酰胺。该方案允许在无过渡金属和无氧化剂的条件下选择性裂解 2,2,2-三氟乙基羰基的 C-C 键，这与类似的 C-F 或 C-CF 3 键功能化相反。该反应揭示了 2,2,2-三氟乙基羰基的未开发反应性，并表现出广泛的底物范围和良好的官能团耐受性。
• 1,3,4-OXADIAZOLE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
  申请人：Chong Kun Dang Pharmaceutical Corp.

  公开号：EP3331864A2

  公开（公告）日：2018-06-13
• METHOD OF CONVERTING CARBON DIOXIDE INTO CARBONYL COMPOUNDS
  申请人：TRANSLATIONAL HEALTH SCIENCE AND TECHNOLOGY INSTITUTE

  公开号：US20190284171A1

  公开（公告）日：2019-09-19

  The present invention provides a method for fixing carbon dioxide gas as a carbonyl compound represented by formula (3) as depicted by FIG. 1 and comprising, purging of carbon dioxide in a solution of a nucleophile represented by the formula (1) in presence of a solvent at a temperature ranging from −40 Degree Celsius to 35 Degree Celsius, followed by adding a reagent at temperature ranging from −40 degree to 35 degree and thereafter adding another nucleophile represented by the formula (2) to obtain carbonyl compound represented by formula (3). The present invention can be advantageously used to obtain commercially important carbonyl compounds and clean unwanted carbon dioxide gas from the atmosphere and industrial effluents.