5,5-Diethyl-1-isopropyl-3-methylbarbitursaeure | 132660-11-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5,5-Diethyl-1-isopropyl-3-methylbarbitursaeure
• 英文别名: 5,5-Diethyl-1-methyl-3-propan-2-yl-1,3-diazinane-2,4,6-trione
• CAS: 132660-11-8
• 化学式: C₁₂H₂₀N₂O₃
• 分子量: 240.302
• InChiKey: IFUAQHCBINEKDR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  57.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  美沙比妥 、 异丙醇 生成 5,5-Diethyl-1-isopropyl-3-methylbarbitursaeure
  参考文献：
  名称：

  SCHLAPFER-DAHLER, MARLISE;HEIMGARTNER, HEINZ, HELV. CHIM. ACTA, 73,(1990) N, C. 2275-2286

  摘要：

  DOI：

文献信息

• Umsetzungen von 3-(Dimethylamino)-2,2-dimethyl-2<i>H</i>-azirin mit Barbitursäure-Derivaten
  作者：Marlise Schläpfer-Dähler、Heinz Heimgartner

  DOI：10.1002/hlca.19900730824

  日期：1990.12.12

  Reactions of 3-(Dimethylamino)-2,2-dimethyl-2H-azirines with Barbituric-Acid Derivatives

  3-（二甲氨基）-2,2-二甲基-2 H-叠氮基与巴比妥酸衍生物的反应
• SCHLAPFER-DAHLER, MARLISE;HEIMGARTNER, HEINZ, HELV. CHIM. ACTA, 73,(1990) N, C. 2275-2286
  作者：SCHLAPFER-DAHLER, MARLISE、HEIMGARTNER, HEINZ

  DOI：——

  日期：——
• Multi-API Loading Prodrugs
  申请人：Zeidan Tarek A.

  公开号：US20120202823A1

  公开（公告）日：2012-08-09

  The present invention accomplishes this by having multiple molecules of parent drugs attached to carrier moieties and by extending the period during which the parent drug is released and absorbed after administration to the patient and providing a longer duration of action per dose than the parent drug itself. Prodrug conjugates are suitable for sustained delivery of heteroaryl, lactam- amide-, imide-, sulfonamide-, carbamate-, urea-, benzamide-, acylaniline-, cyclic amide- and tertiary amine-containing parent drugs that are substituted at the amide nitrogen or oxygen atom with labile aldehyde-linked prodrug moieties. The carrier groups of the prodrugs can be hydrophobic to reduce the polarity and solubility of the parent drug under physiological conditions.
• MULTI-API LOADING PRODRUGS
  申请人：Alkermes Pharma Ireland Limited

  公开号：US20180194732A1

  公开（公告）日：2018-07-12

  The present invention accomplishes this by having multiple molecules of parent drugs attached to carrier moieties and by extending the period during which the parent drug is released and absorbed after administration to the patient and providing a longer duration of action per dose than the parent drug itself. Prodrug conjugates are suitable for sustained delivery of heteroaryl, lactam- amide-, imide-, sulfonamide-, carbamate-, urea-, benzamide-, acylaniline-, cyclic amide- and tertiary amine-containing parent drugs that are substituted at the amide nitrogen or oxygen atom with labile aldehyde-linked prodrug moieties. The carrier groups of the prodrugs can be hydrophobic to reduce the polarity and solubility of the parent drug under physiological conditions.