[1,3]Thiazolo[3,2-a]pyrimidin-4-ium

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: [1,3]Thiazolo[3,2-a]pyrimidin-4-ium
• 化学式: C6H5N2S+
• 分子量: 137.18
• InChiKey: ZOYQGPGGBMOMMD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  45.2
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• NOVEL HETEROCYCLIC SYSTEMS AND PHARMACEUTICAL COMPOSITIONS THEREOF
  申请人：University of Sharjah

  公开号：EP3774819A2

  公开（公告）日：2021-02-17
• [EN] NOVEL HETEROCYCLIC SYSTEMS AND PHARMACEUTICAL COMPOSITIONS THEREOF<br/>[FR] NOUVEAUX SYSTÈMES HÉTÉROCYCLIQUES ET COMPOSITIONS PHARMACEUTIQUES ASSOCIÉES
  申请人：UNIV OF SHARJAH

  公开号：WO2019186384A2

  公开（公告）日：2019-10-03

  Novel heterocyclic systems are herein disclosed, which possess many biological activities, including but not limited to anticancer activity. The disclosed compounds are useful in the treatment of many disease states related to cell proliferation. In particular, new pyran derivatives are provided along with processes for their preparations and methods for their pharmaceutical applications, for example, as anticancer agents. These compounds were found to have antiproliferative effects against multiple cancer cell lines and showed low toxicity to normal fibroblasts. The disclosed compounds also exhibited anticancer properties by inducing caspase-mediated cell death mechanisms and arresting cancer cell progression. Further, these novel compounds were able to target multiple key proteins/enzymes, including thioredoxin reductase, glutathione reductase, transferrin receptors, inisitol-3-phosphate synthase, cystolic aminopeptidase, and transketolase, which are over-expressed in tumor cells.