N-benzyl-N,3-dimethylbutan-1-amine | 134895-08-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-benzyl-N,3-dimethylbutan-1-amine
• 英文别名: benzyl-isopentyl-methyl-amine；Methylisoamylbenzylamin
• CAS: 134895-08-2
• 化学式: C₁₃H₂₁N
• 分子量: 191.316
• InChiKey: IPPXUITZUAHNRW-UHFFFAOYSA-N

物化性质

• 沸点：
  107-109 °C(Press: 12 Torr)
• 密度：
  0.900±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-benzyl-N,3-dimethylbutan-1-amine 在 palladium on activated charcoal 二氯甲烷 、 氢气 作用下， 以 甲醇 为溶剂， 反应 24.0h， 以97%的产率得到methyl(3-methylbutyl)amine hydrochloride
  参考文献：
  名称：

  Nonracemic Betti Base as a New Chiral Auxiliary:  Application to Total Syntheses of Enantiopure (2S,6R)-Dihydropinidine and (2S,6R)-Isosolenopsins

  摘要：

  Total syntheses of enantiopure alkaloidal natural products (2S,6R)-dihydropinidine (as hydrochloride) and (2S,6R)isosolenopsins (as hydrochlorides) were achieved in four steps and in 80-82% total yields by using a synthetic strategy of the formation-cleavage of 1,3-oxazinane. (S)-Betti base was proved to be an excellent chiral auxiliary and a novel Pd/C catalyzed N-debenzylation straightforward to amine hydrochloride was developed in the presence of CH2Cl2.

  DOI：

  10.1021/jo0480444
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 silver(l) oxide 作用下， 生成 N-benzyl-N,3-dimethylbutan-1-amine
  参考文献：
  名称：

  Ishizaka, Chemische Berichte, 1914, vol. 47, p. 2456

  摘要：

  DOI：

文献信息

• [EN] CYCLIC PHOSPHATES AND CYCLIC PHOSPHORAMIDATES FOR THE TREATMENT OF NEUROLOGIC DISORDERS<br/>[FR] PHOSPHATES CYCLIQUES ET PHOSPHORAMIDATES CYCLIQUES POUR LE TRAITEMENT DE TROUBLES NEUROLOGIQUES
  申请人：RETROPHIN INC

  公开号：WO2017099822A1

  公开（公告）日：2017-06-15

  Compounds having the following formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, D, E and R1 are as defined herein, are provided. Methods comprising the use of such compounds for the treatment of neurological disorders, such as pantothenate kinase-associated neurodegeneration, and pharmaceutical compositions containing such compounds, and their use in the treatment of neurological disorders, also are provided.

  提供具有以下化学式（I）的化合物及其药用可接受的盐，其中A、B、D、E和R1的定义如本文所述。提供了使用这些化合物治疗神经系统疾病（如泛酸激酶相关性神经退行性疾病）的方法，以及含有这些化合物的药物组合物，以及它们在治疗神经系统疾病中的用途。
• β‐C−H Allylation of Trialkylamines with Allenes Promoted by Synergistic Borane/Palladium Catalysis
  作者：Ming Zhang、Zi‐Lu Tang、Heng Luo、Xiao‐Chen Wang

  DOI：10.1002/anie.202317610

  日期：2024.1.25

  The β-C−H allylation reactions of trialkylamines with allenes were accomplished by a synergistic borane/palladium catalysis. The borane and palladium catalysts promoted the formation of an enamine intermediate from a trialkylamine and a palladium-π-allyl intermediate from an allene, respectively.

  三烷基胺与丙二烯的 β-C−H 烯丙基化反应是通过硼烷/钯的协同催化完成的。硼烷和钯催化剂分别促进从三烷基胺形成烯胺中间体和从丙二烯形成钯-π-烯丙基中间体。
• Honeybee Repellents and Uses Thereof
  申请人：Inscent, Inc.

  公开号：US20140155261A1

  公开（公告）日：2014-06-05

  The present specification discloses honeybee repellents exhibiting repellent properties similar to 2-heptanone, compositions comprising such repellents, uses to repel a honeybee from a mammal, location, plant, structure treated of such repellents, and methods of treating a mammal, location, plant, structure by applying such repellents.
• US7179815B2
  申请人：——

  公开号：US7179815B2

  公开（公告）日：2007-02-20
• US9439434B2
  申请人：——

  公开号：US9439434B2

  公开（公告）日：2016-09-13