2-Methoxy-1-(2-nitroethenyl)naphthalene | 156482-74-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-Methoxy-1-(2-nitroethenyl)naphthalene
• CAS: 156482-74-5
• 化学式: C₁₃H₁₁NO₃
• mdl: MFCD03716036
• 分子量: 229.235
• InChiKey: WZPDPCQRXRVFIK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.076
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-Methoxy-1-(2-nitroethenyl)naphthalene 在 sodium azide 、 对甲苯磺酸 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 4-(2-methoxynaphthalen-1-yl)-2H-triazole
  参考文献：
  名称：

  DABCO-mediated aza-Michael addition of 4-aryl-1H-1,2,3-triazoles to cycloalkenones. Regioselective synthesis of disubstituted 1,2,3-triazoles

  摘要：

  Aza-Michael addition of 4-aryl-1H-1,2,3-triazoles to 2-cycloalken-1-ones has been studied in the presence of DABCO as organic base. The reactions were carried out in acetonitrile at room temperature to provide 2,4-disubstituted 2H-1,2,3-triazoles as major adducts and 1,4-disubstituted 1H-1,2,3-triazoles as minor adducts. Though the reaction times are longer (4-8 days), the two regioisomers were separated by using column chromatography and the adducts were obtained in very good to excellent combined chemical yields. The electron-rich and electron-poor substituents on aryl moiety of 4-aryl-triazoles could tolerate the reaction conditions to afford the title adducts. (C) 2016 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2016.11.125
• 作为产物：
  描述：

  2-甲氧基-1-萘醛 、 乙酸铵 、 硝基甲烷 在 硝基甲烷 、 乙酸铵 、 二氯甲烷 、 magnesium sulfate 作用下， 以 水 为溶剂， 反应 1.5h， 以1.77 g of yellow crystals (equivalent to 7.73 mmol of the expected product) are then obtained, corresponding to a 95% yield的产率得到
  参考文献：
  名称：

  Arylalkyl(thio) amides

  摘要：

  一种化合物，从式(I)所示的化合物中选择：##STR1## 其中A、R.sub.1、R.sub.2、R.sub.3、R.sub.4、R.sub.5和R.sub.6如说明书中所定义的那样，其光学异构体及其与药用可接受酸或碱的加成盐，以及含有该化合物的药物制剂，可用于治疗褪黑素系统失调。

  公开号：

  US05554642A1

文献信息

• Arylalkyl (thio)amides
  申请人：Adir Et Compagnie

  公开号：US05604261A1

  公开（公告）日：1997-02-18

  A compound which is selected from those of formula (I) : ##STR1## in which A, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are as defined in the description, its optical isomers, and its addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same which are useful for treating a disorder of the melatoninergic system.

  从公式（I）中选择的化合物：##STR1## 其中A，R.sub.1，R.sub.2，R.sub.3，R.sub.4，R.sub.5和R.sub.6如描述中所定义，其光学异构体，以及其与药学上可接受的酸或碱的加合盐，以及包含其的药物制剂，用于治疗褪黑素系统疾病。
• Arylvinylamide derivatives and pharmaceutical use
  申请人：Farmitalia Carlo Erba S.r.l.

  公开号：US05122537A1

  公开（公告）日：1992-06-16

  The invention relates to new arylvinylamide derivatives of formula ##STR1## wherein Y is a bicyclic ring system chosen from (A), (B), (C), (D), and (E); ##STR2## in which m is zero, 1 or 2; R is hydrogen, a C.sub.1 -C.sub.6 alkyl or C.sub.1 -C.sub.6 alkanoyl group; R.sub.1 is hydrogen or C.sub.1 -C.sub.6 alkyl; R.sub.2 is hydrogen, halogen, cyano or C.sub.1 -C.sub.6 alkyl; and n is an integer of 1 to 3; and wherein each of the substituents --CH.dbd.CHNHCOR.sub.1, OR and R.sub.2 may be independently on either of the aryl and heteroaryl moieties of the bicyclic ring system (A), (C), (D) and (E); whereas only the benzene ring may be substituted in the bicyclic ring system (B), which are useful as tyrosine kinase inhibitors.

  本发明涉及新的芳基乙烯酰胺衍生物，其化学式为 ##STR1## 其中Y是从（A）、（B）、（C）、（D）和（E）中选择的双环环系；##STR2## 其中m为零、1或2；R为氢、C.sub.1-C.sub.6烷基或C.sub.1-C.sub.6酰基基团；R.sub.1为氢或C.sub.1-C.sub.6烷基；R.sub.2为氢、卤素、氰或C.sub.1-C.sub.6烷基；n为1至3的整数；其中每个取代基--CH.dbd.CHNHCOR.sub.1、OR和R.sub.2可以独立地存在于双环环系（A）、（C）、（D）和（E）的芳基和杂环芳基之一上；而仅苯环可以被取代在双环环系（B）中，这些衍生物可用作酪氨酸激酶抑制剂。