Methyl 2-(acetylamino)-5-methylthiophene-3-carboxylate

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Methyl 2-(acetylamino)-5-methylthiophene-3-carboxylate
• 英文别名: methyl 2-acetamido-5-methylthiophene-3-carboxylate
• 化学式: C₉H₁₁NO₃S
• mdl: MFCD02325914
• 分子量: 213.26
• InChiKey: XKZIMVVOZHFEIW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  83.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Methyl 2-(acetylamino)-5-methylthiophene-3-carboxylate 以39%的产率得到
  参考文献：
  名称：

  NIELSEN K. E.; PEDERSEN E. B., ACTA CHEM. SCAND., 1978, B 32, NO 4, 303-305

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氨基-5-甲基噻吩-3-羧酸甲酯 、 乙酸酐 、 溶剂黄146 生成 Methyl 2-(acetylamino)-5-methylthiophene-3-carboxylate
  参考文献：
  名称：

  NIELSEN K. E.; PEDERSEN E. B., ACTA CHEM. SCAND., 1978, B 32, NO 4, 303-305

  摘要：

  DOI：

文献信息

• Thienopyrimidinone compounds
  申请人：BioTheryX, Inc.

  公开号：US10584133B2

  公开（公告）日：2020-03-10

  The present disclosure provides compounds that modulate protein function and/or restore protein homeostasis. The disclosure provides methods of modulating protein-mediated diseases, disorders, conditions, or responses. Compositions, including in combination with other therapeutic agents, are provided.

  本公开提供了调节蛋白质功能和/或恢复蛋白质平衡的化合物。本公开提供了调节蛋白质介导的疾病、失调、状况或反应的方法。还提供了包括与其他治疗剂结合使用的组合物。
• THIENOPYRIMIDINONE COMPOUNDS
  申请人：Biotheryx, Inc.

  公开号：EP3774815A1

  公开（公告）日：2021-02-17
• FUSED 1,4-OXAZEPINES AND RELATED ANALOGS AS BET BROMODOMAIN INHIBITORS
  申请人：THE REGENTS OF THE UNIVERSITY OF MICHIGAN

  公开号：US20210188870A1

  公开（公告）日：2021-06-24

  The present disclosure provides fused 1,4-oxazepines and related analogs represented by Formula (I) and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R 1 , R 2a , R 2b , R 3a , R 3b , R 4 , R 5 , A, and Y are as defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a condition or disorder responsive to inhibition of BET bromodomains such as cancer.
• [EN] THIENOPYRIMIDINONE COMPOUNDS<br/>[FR] COMPOSÉS DE THIÉNOPYRIMIDINONE
  申请人：BIOTHERYX INC

  公开号：WO2019191451A1

  公开（公告）日：2019-10-03

  The present disclosure provides compounds that modulate protein function and/or restore protein homeostasis. The disclosure provides methods of modulating protein-mediated diseases, disorders, conditions, or responses. Compositions, including in combination with other therapeutic agents, are provided.
• NIELSEN K. E.; PEDERSEN E. B., ACTA CHEM. SCAND., 1978, B 32, NO 4, 303-305
  作者：NIELSEN K. E.、 PEDERSEN E. B.

  DOI：——

  日期：——