4-(biphenyl-2-yloxy)aniline | 212189-56-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(biphenyl-2-yloxy)aniline
• 英文别名: 4-(2-Phenylphenoxy)aniline
• CAS: 212189-56-5
• 化学式: C₁₈H₁₅NO
• mdl: MFCD02663334
• 分子量: 261.323
• InChiKey: ZWQOXRDNGHWDBS-UHFFFAOYSA-N

物化性质

• 溶解度：
  10.4 [ug/mL]

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT

反应信息

• 作为反应物：
  描述：

  4-(biphenyl-2-yloxy)aniline 、 (Z)-ethyl 6-(tosyloxy)hex-2-enoate 在 碳酸氢钠 、 sodium hydroxide 作用下， 以 1,4-二氧六环 、 水 、 乙酸乙酯 为溶剂， 反应 2.33h， 生成 (S)-2-(1-(4-(biphenyl-2-yloxy)phenyl)pyrrolidin-2-yl)acetic acid hydrochloride
  参考文献：
  名称：

  Discovery of Pyrrolidine-Containing GPR40 Agonists: Stereochemistry Effects a Change in Binding Mode

  摘要：

  A novel series of pyrrolidine-containing GPR40 agonists is described as a potential treatment for type 2 diabetes. The initial pyrrolidine hit was modified by moving the position of the carboxylic acid, a key pharmacophore for GPR40. Addition of a 4-cis-CF3 to the pyrrolidine improves the human GPR40 binding K-i and agonist efficacy. After further optimization, the discovery of a minor enantiomeric impurity with agonist activity led to the finding that enantiomers (R,R)-68 and (S,S)-68 have differential effects on the radioligand used for the binding assay, with (R,R)-68 potentiating the radioligand and (S,S)-68 displacing the radioligand. Compound (R,R)-68 activates both G(q)-coupled intracellular Ca2+ flux and G(s)-coupled cAMP accumulation. This signaling bias results in a dual mechanism of action for compound (R,R)-68, demonstrating glucose-dependent insulin and GLP-1 secretion in vitro. In vivo, compound (R,R)-68 significantly lowers plasma glucose levels in mice during an oral glucose challenge, encouraging further development of the series.

  DOI：

  10.1021/acs.jmedchem.6b01559
• 作为产物：
  描述：

  2-(4-nitrophenoxy)biphenyl 在 锌 作用下， 以 溶剂黄146 为溶剂， 以84%的产率得到4-(biphenyl-2-yloxy)aniline
  参考文献：
  名称：

  Discovery of Pyrrolidine-Containing GPR40 Agonists: Stereochemistry Effects a Change in Binding Mode

  摘要：

  A novel series of pyrrolidine-containing GPR40 agonists is described as a potential treatment for type 2 diabetes. The initial pyrrolidine hit was modified by moving the position of the carboxylic acid, a key pharmacophore for GPR40. Addition of a 4-cis-CF3 to the pyrrolidine improves the human GPR40 binding K-i and agonist efficacy. After further optimization, the discovery of a minor enantiomeric impurity with agonist activity led to the finding that enantiomers (R,R)-68 and (S,S)-68 have differential effects on the radioligand used for the binding assay, with (R,R)-68 potentiating the radioligand and (S,S)-68 displacing the radioligand. Compound (R,R)-68 activates both G(q)-coupled intracellular Ca2+ flux and G(s)-coupled cAMP accumulation. This signaling bias results in a dual mechanism of action for compound (R,R)-68, demonstrating glucose-dependent insulin and GLP-1 secretion in vitro. In vivo, compound (R,R)-68 significantly lowers plasma glucose levels in mice during an oral glucose challenge, encouraging further development of the series.

  DOI：

  10.1021/acs.jmedchem.6b01559

文献信息

• Novel polyimide compositions and novel acid dianhydrides to be used therein
  申请人：KANEKA CORPORATION

  公开号：US20020055610A1

  公开（公告）日：2002-05-09

  Novel polyimides substituted by a substituent having an alkyl or fluoroalkyl group and having reduced water absorption; a process for producing these novel polyimides; and novel acid dianhydrides to be used in the production thereof. A polyimide containing a structure represented by the following general formula (I): 1 wherein X 1 represents a tetravalent organic group having a substituent —R 1 AR 2 (wherein A represents a divalent linkage group; R 1 represents a single bond or a C 1-3 alkylene group; and R 2 represents a C 1-25 alkyl group or a fluoroalkyl group); and Y represents a divalent organic group.

  新型聚酰亚胺，其被取代基含有烷基或氟烷基，且具有降低吸水性；制备这些新型聚酰亚胺的方法；以及用于制备新型聚酰亚胺的新型酸二酐。聚酰亚胺包含以下一般式(I)所表示的结构：1其中，X1代表一个四价有机基团，其具有一个取代基-R1AR2（其中A代表二价连接基；R1代表单键或C1-3烷基；R2代表C1-25烷基或氟烷基）；Y代表二价有机基团。
• [EN] CURABLE RESIN COMPOSITION, CURED OBJECT, LAYERED PRODUCT, METHOD FOR PRODUCING CURED OBJECT, SEMICONDUCTOR DEVICE, AND PHOTOBASE GENERATOR<br/>[FR] COMPOSITION DE RÉSINE DURCISSABLE, OBJET DURCI AINSI QUE PROCÉDÉ DE FABRICATION DE CELUI-CI, STRATIFIÉ, DISPOSITIF À SEMI-CONDUCTEURS, ET GÉNÉRATEUR DE PHOTOBASE<br/>[JA] 硬化性樹脂組成物、硬化物、積層体、硬化物の製造方法、及び、半導体デバイス、並びに、光塩基発生剤
  申请人：FUJIFILM CORP

  公开号：WO2022050278A1

  公开（公告）日：2022-03-10

  ポリイミド前駆体、ポリベンゾオキサゾール前駆体及びポリアミドイミド前駆体よりなる群から選ばれた少なくとも１種の樹脂、及び、アルコキシシリル基を有する光塩基発生剤を含む、硬化性樹脂組成物、上記硬化性樹脂組成物を硬化してなる硬化物、上記硬化物を含む積層体、上記硬化物の製造方法、及び、上記硬化物又は上記積層体を含む半導体デバイス、並びに、光塩基発生剤。

  选择至少一种由聚酰亚胺前体、聚苯并噁嗪前体和聚酰亚胺咪唑前体组成的树脂，以及含有烷氧基硅基的光碱发生剂的硬化树脂组合物，通过硬化上述硬化树脂组合物得到的硬化物，包含上述硬化物的层压体，制造上述硬化物的方法，以及包含上述硬化物或上述层压体的半导体器件，以及光碱发生剂。
• Melt-fusible polyimides
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0122060A2

  公开（公告）日：1984-10-17

  Melt-fusible polyimides based on pyromellitic dianhydride and at least one defined aromatic diamine are useful in making low-void composites and thermoplastic tapes, which can be fabricated into articles such as, for example, aircraft and autobody panels, printed circuit boards, etc. Some of these polyimides are melt-processible and can be fabricated by conventional procedures such as extrusion and injection molding.

  基于吡咯烷二酸酐和至少一种确定的芳香族二胺的可熔融聚酰亚胺可用于制造低空隙复合材料和热塑性胶带，这些材料可制成诸如飞机和汽车车身面板、印刷电路板等物品。其中一些聚酰亚胺可熔融加工，可通过挤出和注塑等传统工艺制造。
• Light-absorbing resins for display device, display devices using the resin and method of manufacturing the same
  申请人：KABUSHIKI KAISHA TOSHIBA

  公开号：EP0231953A2

  公开（公告）日：1987-08-12

  For the display apparatus that uses an electro-optic modulating material such as liquid crystal, use is made of a thin film transistor which possesses a good response, as the driving element. In this transistor, there is provided a light-absorbing resin layer that is formed by a polyimide and a light absorber to prevent malfunctions due to light. A method of manufacturing the display apparatus is disclosed.

  在使用液晶等电光调制材料的显示装置中，使用了具有良好响应的薄膜晶体管作为驱动元件。在这种晶体管中，有一个由聚酰亚胺和光吸收剂形成的光吸收树脂层，以防止光引起的故障。此外，还公开了一种制造显示装置的方法。
• Novel polyamide-polyamide and polybenzoxazole-polyamide polymers
  申请人：HOECHST CELANESE CORPORATION

  公开号：EP0387061A2

  公开（公告）日：1990-09-12

  The present invention provides polyamide-polyamide and polybenzoxazole-polyamide polymers derived therefrom with improved processing and film characteristics having incorporated into the polymeric backbone the polymeric condensation residuum of novel aromatic diamino compounds having the formula: wherein A is selected from the group consisting of S02, 0, S, CO, C1 to C6 alkyl, perfluoroalkyl or perfluoroarylalkyl having from 1 to 10 carbon atoms and a carbon-carbon double bond directly linking the two aromatic groups and R is selected from the group consisting of hydrogen, hydroxy and C1 to C4 alkoxy. The polyamide-polyamide polymers of this invention are prepared by reacting compounds of the above formula, alone or admixed with other aromatic diamines, with one or more aromatic or aliphatic dicarboxylic acids or amide-forming derivatives thereof. Polybenzoxazole-polyamide derivatives of such polyamide-polyamide polymers are prepared utilizing compounds of the above formula wherein R is hydroxy or C, to C4 alkoxy, and by subjecting the resulting alkoxy or hydroxy-substituted polyamide-polyamide to a dehydrating and cyclizing reaction to form the oxazole linkage which gives rise to polybenzoxazole-polyamide polymer.

  本发明提供了聚酰胺-聚酰胺和聚苯并恶唑-聚酰胺聚合物，其聚合物骨架中加入了新型芳香族二氨基化合物的聚合物缩合残余物，具有更好的加工和薄膜特性： 其中 A 选自 S02、0、S、CO、C1 至 C6 烷基、全氟烷基或全氟芳烷基组成的组，这些烷基具有 1 至 10 个碳原子和直接连接两个芳香基团的碳碳双键；R 选自氢、羟基和 C1 至 C4 烷氧基组成的组。 本发明的聚酰胺-聚酰胺聚合物是由上式化合物（单独或与其他芳香族二胺混合）与一种或多种芳香族或脂肪族二羧酸或其酰胺衍生物反应制备而成。这种聚酰胺-聚酰胺聚合物的聚苯并噁唑-聚酰胺衍生物是利用上式化合物制备的，其中R是羟基或C,至C4烷氧基，将得到的烷氧基或羟基取代的聚酰胺-聚酰胺进行脱水和环化反应，形成噁唑连接，从而得到聚苯并噁唑-聚酰胺聚合物。