1H-Benzoimidazole, 2-[(1,3-dihydrobenzoimidazol-2-ylidene)nitrosomethyl]-

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1H-Benzoimidazole, 2-[(1,3-dihydrobenzoimidazol-2-ylidene)nitrosomethyl]-
• 英文别名: N-[bis(1H-benzimidazol-2-yl)methylidene]hydroxylamine
• 化学式: C₁₅H₁₁N₅O
• 分子量: 277.28
• InChiKey: WIZFHSAFKKUPRU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  90
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• COMPOSITIONS FOR PREVENTING AND TREATING TYPE I ALLERGY
  申请人：Sunstar Inc.

  公开号：EP1172109A1

  公开（公告）日：2002-01-16

  A method for screening a cysteine protease inhibitor of which cysteine protease inhibitory activity is enhanced in the presence of endogenous polyvalent metal ion, which comprises treating a cysteine protease with a test compound in the presence of the polyvalent metal ion, and a pharmaceutical composition for treating apoptosis-associated diseases, which contains as the active ingredient a cysteine protease inhibitor of which cysteine protease inhibitory activity is enhanced in the presence of endogenous polyvalent metal ion.

  一种筛选半胱氨酸蛋白酶抑制剂的方法，其半胱氨酸蛋白酶抑制活性在内源性多价金属离子存在下得到增强，该方法包括在多价金属离子存在下用测试化合物处理半胱氨酸蛋白酶，以及一种治疗细胞凋亡相关疾病的药物组合物，其活性成分含有半胱氨酸蛋白酶抑制剂，其半胱氨酸蛋白酶抑制活性在内源性多价金属离子存在下得到增强。
• METHOD FOR SCREENING CYSTEINE PROTEASE INHIBITOR
  申请人：YAMANOUCHI PHARMACEUTICAL CO. LTD.

  公开号：EP1172443A1

  公开（公告）日：2002-01-16

  A method for screening a cysteine protease inhibitor of which cysteine protease inhibitory activity is enhanced in the presence of endogenous polyvalent metal ion, which comprises treating a cysteine protease with a test compound in the presence of the polyvalent metal ion, and a pharmaceutical composition for treating apoptosis-associated diseases, which contains as the active ingredient a cysteine protease inhibitor of which cysteine protease inhibitory activity is enhanced in the presence of endogenous polyvalent metal ion.

  一种筛选半胱氨酸蛋白酶抑制剂的方法，其半胱氨酸蛋白酶抑制活性在内源性多价金属离子存在下得到增强，该方法包括在多价金属离子存在下用测试化合物处理半胱氨酸蛋白酶，以及一种治疗细胞凋亡相关疾病的药物组合物，其活性成分含有半胱氨酸蛋白酶抑制剂，其半胱氨酸蛋白酶抑制活性在内源性多价金属离子存在下得到增强。