5-吡啶-4-基-1H-咪唑-2-胺 | 103851-74-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 5-吡啶-4-基-1H-咪唑-2-胺
• 英文名称: 4-(pyridin-4-yl)-1H-imidazol-2-amine
• 英文别名: 2-amino-4-(4-pyridyl)imidazole；1H-Imidazol-2-amine, 4-(4-pyridinyl)-；5-pyridin-4-yl-1H-imidazol-2-amine
• CAS: 103851-74-7
• 化学式: C₈H₈N₄
• 分子量: 160.178
• InChiKey: AYMDMLFHNZJJEF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  67.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  氰胺 、 4-Aminoacetyl-pyridine hydrochloride 在 sodium hydroxide 作用下， 反应 1.0h， 以50%的产率得到5-吡啶-4-基-1H-咪唑-2-胺
  参考文献：
  名称：

  Bioisosteric prototype design of biaryl imidazolyl and triazolyl competitive histamine H2-receptor antagonists

  摘要：

  The structural relationship of the competitive histamine H2-receptor antagonist 3-amino-5-(2-amino-4-pyridyl)-1,2,4-triazole (1) to the agonist histamine and to antagonists of the cimetidine type was explored by the design and synthesis of four series of bioisosterically designed prototypes. Biological data from these series was best interpreted as indicating a similarity between the imidazole moiety of histamine and cimetidine and the 2-amino-4-pyridyl moiety of 1. On the basis of this data, sequential replacement of 2-amino-4-pyridyl by 2-[(dimethylamino)methyl]-5-furyl and 2-guanidino-4-triazolyl moieties led to a structurally more potent series of biaryl histamine H2-receptor antagonists. The best of these, 2-methyl-4-(2-guanidino-4-thiazolyl)imidazole (29, CP-57,361-1) was 120 times more potent as a histamine H2-receptor antagonist than 1.

  DOI：

  10.1021/jm00161a005

文献信息

• Compositions useful as inhibitors of rock and other protein kinases
  申请人：Green Jeremy

  公开号：US20060019956A1

  公开（公告）日：2006-01-26

  The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

  本发明涉及作为蛋白激酶抑制剂有用的化合物。本发明还提供了包含所述化合物的药学上可接受的组合物，并且提供了使用这些组合物治疗各种疾病、状况或障碍的方法。
• COMPOSITIONS USEFUL AS INHIBITORS OF ROCK AND OTHER PROTEIN KINASES
  申请人：VERTEX PHARMACEUTICALS INCORPORATED

  公开号：EP1751133B1

  公开（公告）日：2010-04-14
• US7531556B2
  申请人：——

  公开号：US7531556B2

  公开（公告）日：2009-05-12