N-[2-[3,5-dichloro-4-[3-(1,3-dioxoisoindol-2-yl)propoxy]phenyl]ethyl]acetamide | 437712-26-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: N-[2-[3,5-dichloro-4-[3-(1,3-dioxoisoindol-2-yl)propoxy]phenyl]ethyl]acetamide
• CAS: 437712-26-0
• 化学式: C₂₁H₂₀Cl₂N₂O₄
• 分子量: 435.307
• InChiKey: WYGIYXWYDLAWHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  75.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-[2-[3,5-dichloro-4-[3-(1,3-dioxoisoindol-2-yl)propoxy]phenyl]ethyl]acetamide 在 盐酸 作用下， 生成
  参考文献：
  名称：

  Cytotoxic, antifouling bromotyramines: A synthetic study on simple marine natural products and Their analogues

  摘要：

  Synthesis and biological evaluation of two naturally-occurring bromotyramines. moloka'iamine 1 and 3,5-dibromo-4-methoxy-beta-phenethylamine 2, together with several analogues, have been completed. Bromotyramine 2 is cytotoxic, and was found to be a potent antifoulant. Analogues 15 and 16 also displayed significant cytotoxic and antifouling activities. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00022-7
• 作为产物：
  描述：

  N-乙酰基酪胺 在 磺酰氯 、 potassium carbonate 、 potassium iodide 作用下， 以 乙醚 、 乙腈 为溶剂， 生成 N-[2-[3,5-dichloro-4-[3-(1,3-dioxoisoindol-2-yl)propoxy]phenyl]ethyl]acetamide
  参考文献：
  名称：

  Cytotoxic, antifouling bromotyramines: A synthetic study on simple marine natural products and Their analogues

  摘要：

  Synthesis and biological evaluation of two naturally-occurring bromotyramines. moloka'iamine 1 and 3,5-dibromo-4-methoxy-beta-phenethylamine 2, together with several analogues, have been completed. Bromotyramine 2 is cytotoxic, and was found to be a potent antifoulant. Analogues 15 and 16 also displayed significant cytotoxic and antifouling activities. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00022-7

文献信息

• Cytotoxic, antifouling bromotyramines: A synthetic study on simple marine natural products and Their analogues
  作者：Ryan C. Schoenfeld、Susan Conova、Daniel Rittschof、Bruce Ganem

  DOI：10.1016/s0960-894x(02)00022-7

  日期：2002.3

  Synthesis and biological evaluation of two naturally-occurring bromotyramines. moloka'iamine 1 and 3,5-dibromo-4-methoxy-beta-phenethylamine 2, together with several analogues, have been completed. Bromotyramine 2 is cytotoxic, and was found to be a potent antifoulant. Analogues 15 and 16 also displayed significant cytotoxic and antifouling activities. (C) 2002 Elsevier Science Ltd. All rights reserved.